ArticleOncogene1999
Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future.Frontiers in oncology · 2022Review
- IPF pathogenesis is dependent upon TGFβ induction of IGF-1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Establishment and Characterization of Two Novel Cholangiocarcinoma Cell Lines.Annals of surgical oncology · 2019Article
- Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases.BioMed research international · 2018Review
- IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide.Oncotarget · 2015Article
- Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells.Cancer letters · 2014Article
- Article
- miR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase 2.Oncology letters · 2013Article
- Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.Cell cycle (Georgetown, Tex.) · 2012Article
- Anoikis resistance: an essential prerequisite for tumor metastasis.International journal of cell biology · 2012Article
- Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-α-mediated neuronal damage: implications for human immunodeficiency virus encephalitis.Journal of neuroscience research · 2011Article
- Will targeting insulin growth factor help us or hurt us?: An oncologist's perspective.Ageing research reviews · 2011Review
- Article
- PTK6 regulates IGF-1-induced anchorage-independent survival.PloS one · 2010Article
- ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro.Molecular cancer · 2010Article
- Article
- Regulation of breast cancer metastasis by IGF signaling.Journal of mammary gland biology and neoplasia · 2008Review
- Gene expression analysis of pancreatic cystic neoplasm in SV40Tag transgenic mice model.World journal of gastroenterology · 2007Article
- Article
- The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.Molecular and cellular biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The type 1 insulin-like growth factor receptor (IGF-IR) is known to protect cells from a variety of apoptotic injuries. In several instances, the anti-apoptotic effect of the wild type IGF-IR is more evident under conditions of anchorage-independence than in cells in monolayer cultures. We have investigated IGF-IR signaling in cells in anoikis, a form of apoptosis that occurs when cells are denied attachment to the extra-cellular matrix. IGF-I protects mouse embryo fibroblasts (MEF) from anoikis caused by withdrawal of growth factors. Survival is dependent on the concentration of IGF-I and a sufficient number of functional IGF-I receptors. In this model, IGF-I protection correlates best with ras activation and cell-to-cell aggregation, while PI3-kinase, Akt and MAP kinases seem to play a lesser, alternative role.
Indexed as
Identifiers
10086337What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.