ReviewMolecular and cellular biochemistry1999
Structural basis of the function of endothelin receptor.
Review in Molecular and cellular biochemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Endothelin-1 downregulates sperm phagocytosis by neutrophils in vitro: A physiological implication in bovine oviduct immunity.The Journal of reproduction and development · 2016Article
- Endothelin contributes to blunted renal autoregulation observed with a high-salt diet.American journal of physiology. Renal physiology · 2015Article
- Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension.Journal of cellular physiology · 2013Article
- Peripheral mechanisms of itch.Neuroscience bulletin · 2012Review
- Molecular characterization of two endothelin pathways in East African cichlid fishes.Journal of molecular evolution · 2011Article
- Endothelins in regulating ovarian and oviductal function.Frontiers in bioscience (Scholar edition) · 2011Review
- Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish.American journal of medical genetics. Part A · 2010Review
- Identification of a novel role for endothelins within the oviduct.Endocrinology · 2010Article
- Endothelin receptors: what's new and what do we need to know?American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelin receptor is a good model for analysis of the function of heptahelical G-protein coupled receptor. In ligand binding to the heptahelical receptor, the receptor has two functions, i.e. 'message' and 'address' functions. Each function has been assigned to different domain of the receptor. A different part of the ligand structure also corresponds to each domain of the receptor. Classically, classification of receptor has been done according to the difference of address domain, i.e. affinity difference of the receptor. However, present results predict that the classification of receptor is also possible according to the message domain. After stimulation of ET receptor by a ligand, the receptor transmits a signal to G-protein. Several kinds of G-proteins can possibly be activated. Different structural domains of the receptor are assigned to the coupling of the different Galpha-protein. Activated G-protein transmits the message to effector. Each Galpha-protein acts on different target molecules, resulting in different responses. However, the activation of each Galpha-protein presumably depends on its intracellular level. Even if the same receptor is activated with the same ligand, resulting final response is different from cell to cell. Therefore, classification of receptor according to the function of the receptor is difficult.
Indexed as
Identifiers
10098982W1522018513What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.