ArticleMolecular and cellular biology1999
The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer.Experimental dermatology · 2021Review
- RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity.International journal of molecular sciences · 2019Article
- Novel function of E26 transformation-specific domain-containing protein ELK3 in lymphatic endothelial cells.Oncology letters · 2018Article
- Phosphorylation of the oncogenic transcription factor ERG in prostate cells dissociates polycomb repressive complex 2, allowing target gene activation.The Journal of biological chemistry · 2017Article
- The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo.Oncotarget · 2016Article
- XRP44X, an Inhibitor of Ras/Erk Activation of the Transcription Factor Elk3, Inhibits Tumour Growth and Metastasis in Mice.PloS one · 2016Article
- Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells.Cell communication and signaling : CCS · 2015Article
- ELK3 Expression Correlates With Cell Migration, Invasion, and Membrane Type 1-Matrix Metalloproteinase Expression in MDA-MB-231 Breast Cancer Cells.Gene expression · 2015Article
- Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch.Current biology : CB · 2012Article
- Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.Experimental cell research · 2012Article
- Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism.Molecular cancer · 2011Article
- Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage.Molecular and cellular neurosciences · 2010Article
- The ternary complex factor net is downregulated by hypoxia and regulates hypoxia-responsive genes.Molecular and cellular biology · 2007Article
- Genotoxic stress and cellular stress alter the subcellular distribution of human T-cell leukemia virus type 1 tax through a CRM1-dependent mechanism.Journal of virology · 2006Article
- The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism.Molecular and cellular biology · 2004Article
- The tumor suppressor p53 inhibits Net, an effector of Ras/extracellular signal-regulated kinase signaling.Molecular and cellular biology · 2004Article
- ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression.Molecular and cellular biology · 2004Article
- Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5.The Journal of cell biology · 2003Article
- Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.Journal of mammary gland biology and neoplasia · 2003Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ternary complex factors (TCFs) are targets for Ras/mitogen-activated protein kinase signalling pathways. They integrate the transcriptional response at the level of serum response elements in early-response genes, such as the c-fos proto-oncogene. An important aim is to understand the individual roles played by the three TCFs, Net, Elk1, and Sap1a. Net, in contrast to Elk1 and Sap1a, is a strong repressor of transcription. We now show that Net is regulated by nuclear-cytoplasmic shuttling in response to specific signalling pathways. Net is mainly nuclear under both normal and basal serum conditions. Net contains two nuclear localization signals (NLSs); one is located in the Ets domain, and the other corresponds to the D box. Net also has a nuclear export signal (NES) in the conserved Ets DNA binding domain. Net is apparently unique among Ets proteins in that a particular leucine in helix 1, a structural element, generates a NES. Anisomycin, UV, and heat shock induce active nuclear exclusion of Net through a pathway that involves c-Jun N-terminal kinase kinase and is inhibited by leptomycin B. Nuclear exclusion relieves transcriptional repression by Net. The specific induction of nuclear exclusion of Net by particular signalling pathways shows that nuclear-cytoplasmic transport of transcription factors can add to the specificity of the response to signalling cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.