ArticleProceedings of the National Academy of Sciences of the United States of America1999
RNA diversity has profound effects on the translation of neuronal nitric oxide synthase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 178 citations in OpenAlex.
- Lipin1 restores nNOS sarcolemmal localization and improves fatigue resistance in Duchenne muscular dystrophy.American journal of physiology. Cell physiology · 2026Article
- The Physiological Function of nNOS-Associated CAPON Proteins and the Roles of CAPON in Diseases.International journal of molecular sciences · 2023Review
- Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis.International journal of molecular sciences · 2022Article
- Molecular Signaling and Transcriptional Regulation of Histamine HCurrent topics in behavioral neurosciences · 2022Review
- Signaling Pathway of Histamine HCurrent issues in molecular biology · 2021Article
- Tissue-selective alternate promoters guide NLRP6 expression.Life science alliance · 2021Article
- Pharmacological NOS-1 Inhibition Within the Hippocampus Prevented Expression of Cocaine Sensitization: Correlation with Reduced Synaptic Transmission.Molecular neurobiology · 2020Article
- Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice.Nitric oxide : biology and chemistry · 2018Article
- miR-708-5p and miR-34c-5p are involved in nNOS regulation in dystrophic context.Skeletal muscle · 2018Article
- Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns.RNA biology · 2016Article
- Article
- Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology.The Journal of physiology · 2014Review
- Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Neuronal nitric oxide synthase is phosphorylated in response to insulin stimulation in skeletal muscle.Biochemical and biophysical research communications · 2013Article
- Renal redox response to normal pregnancy in the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Exercise-induced angiogenesis correlates with the up-regulated expression of neuronal nitric oxide synthase (nNOS) in human skeletal muscle.European journal of applied physiology · 2012Article
- Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Research progress on neurobiology of neuronal nitric oxide synthase.Neuroscience bulletin · 2011Review
- Leptin induces phosphorylation of neuronal nitric oxide synthase in defined hypothalamic neurons.Endocrinology · 2010Article
- Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases.American journal of physiology. Renal physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
A comprehensive analysis of the structure of neuronal nitric oxide synthase (nNOS; EC 1.14.13.39) mRNA species revealed NOS1 to be the most structurally diverse human gene described to date in terms of promoter usage. Nine unique exon 1 variants are variously used for transcript initiation in diverse tissues, and each is expressed from a unique 5'-flanking region. The dependence on unique genomic regions to control transcription initiation in a cell-specific fashion burdens the transcripts with complex 5'-mRNA leader sequences. Elaborate splicing patterns that involve alternatively spliced leader exons and exon skipping have been superimposed on this diversity. Highly structured nNOS mRNA 5'-untranslated regions, which have profound effects on translation both in vitro and in cells, contain cis RNA elements that modulate translational efficiency in response to changes in cellular phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.