Evidence map›Paper›PMID 10589696›Full record

ArticleJournal of the American Society of Nephrology : JASN1999

Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption.

V Vallon, K Richter, R C Blantz, S Thomson, H Osswald

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02911792 (Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration), which is not on this map. Cited by 170 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02911792 phase4completedstarted 2016, after this paper: background citation

Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With Hyperfiltration

Ran2016Enrolled72Registered outcomes1Posted comparisons0ConditionsDiabetes Mellitus, Type 2Armsdapagliflozin, Glipizide 5 MG, Metformin
PMID 18769499PMID 10792600PMID 10352583PMID 19198800PMID 2030719PMID 20496053PMID 21606218PMID 2190281PMID 21940401PMID 22773704PMID 24334174PMID 24334175other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 1 synthesis or guideline pooled it, 349 citations in OpenAlex.

  1. Pooled it
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  16. A brief history of the cortical thick ascending limb: a systems-biology perspective.American journal of physiology. Renal physiology · 2025
    Review
  17. Handling the sugar rush: the role of the renal proximal tubule.American journal of physiology. Renal physiology · 2024
    Review
  18. SGLT2 Inhibitors and How They Work Beyond the Glucosuric Effect. State of the Art.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Review
  19. Review
  20. Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

V VallonDepartment of Pharmacology, University of Tübingen, Germany. volker.vallon@uni-tuebingen.de
K Richter
R C Blantz
S Thomson
H Osswald
University of Tübingen · DE

Funding

GLOMERULAR AND TUBULAR FUNCTION IN THE DIABETIC KIDNEYR01DK056248 · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · 1999 to 2005
$1.4M
NIDDK NIH HHS DK56248
6 · The paper itself

Abstract

An increase in Na+/glucose cotransport upstream to the macula densa might contribute to the increase in single nephron GFR (SNGFR) in early diabetes mellitus by lowering the signal of the tubuloglomerular feedback, i.e., the luminal Na+, Cl-, and K+ concentration sensed by the macula densa. To examine this issue, micropuncture experiments were performed in nephrons with superficial glomeruli of streptozotocin-induced diabetes mellitus in rats. First, in nondiabetic control rats, ambient early distal tubular concentrations of Na+, Cl-, and K+ were about 21, 20, and 1.2 mM, respectively, suggesting collection sites relatively close to the macula densa. Second, glomerular hyperfiltration in diabetic rats was associated with a reduction in ambient early distal tubular concentrations of Na+, Cl-, and K+ by 20 to 28%, reflecting an increase in fractional reabsorption of these ions up to the early distal tubule. Third, in diabetic rats, early proximal tubular application of phlorizin, an inhibitor of Na+/glucose cotransport, elicited (1) a greater reduction in absolute and fractional reabsorption of Na+, Cl-, and K+ up to the early distal tubule, and (2) a greater increase in early distal tubular concentration of these ions, which was associated with a more pronounced reduction in SNGFR. These findings support the concept that stimulation of tubular Na+/glucose cotransport by reducing the tubuloglomerular feedback signal at the macula densa may contribute to glomerular hyperfiltration in diabetic rats. Glomerular hyperfiltration in diabetic rats serves to compensate for the rise in fractional tubular reabsorption to partly restore the electrolyte load to the distal nephron.

Indexed as

Glomerular Filtration RateAnimalsBiological Transport, ActiveChloridesDiabetes Mellitus, ExperimentalFeedbackGlucoseHydrostatic PressureKidney GlomerulusKidney TubulesMaleModels, BiologicalNephronsPhlorhizinPotassiumRatsChloridesGlucosePhlorhizinPotassiumSodium

Identifiers

PMID10589696
OpenAlexW2164080605

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.