ArticleThe American journal of physiology1999
Role of capillaries in determining CBF reserve: new insights using myocardial contrast echocardiography.
Article in The American journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04575844 (Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome), which is not on this map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
Who cites it
52 citing papers in PubMed, 186 citations in OpenAlex.
- Myocardial contrast echocardiography assessment of perfusion abnormalities in hypertrophic cardiomyopathy.Cardiovascular ultrasound · 2022Trial
- Combination Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD (HIDE): A Randomized, Placebo-Controlled, Pilot Trial.Kidney360 · 2020Trial
- Effect of modest alcohol consumption over 1-2 weeks on the coronary microcirculation of normal subjects.European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology · 2010Trial
- Impaired coronary flow reserve by hyperviscosity in a mouse model of non-light chain multiple myeloma: a mechanism of coronary flow impairment at the capillary level.Cardiovascular research · 2025Article
- The role of transient receptor potential melastatin channels in compressive force-induced contraction of primary cardiac pericytes.Physiological reports · 2025Article
- Cardiac Microvascular Dysfunction and Cardiomyopathy in Diabetes: Is Ferroptosis a Therapeutic Target?Diabetes · 2023Article
- Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes.JACC. Basic to translational science · 2023Review
- Microbubble Enhanced Echocardiography in Current Cardiology Practice.Reviews in cardiovascular medicine · 2022Review
- Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction: What are the Experimental Proofs?Frontiers in physiology · 2022Review
- Persistent Coronary Vasomotor Tone During Myocardial Ischemia Occurs at the Capillary Level and May Involve Pericytes.Frontiers in cardiovascular medicine · 2022Article
- Diabetes pathogenesis and management: the endothelium comes of age.Journal of molecular cell biology · 2021Article
- Perinatal maternal undernutrition does not result in offspring capillary rarefaction in the middle-aged male baboon at rest.Journal of developmental origins of health and disease · 2021Article
- The role of pericytes in hyperemia-induced capillary de-recruitment following stenosis.Current tissue microenvironment reports · 2020Article
- GLP-1 and insulin regulation of skeletal and cardiac muscle microvascular perfusion in type 2 diabetes.Journal of diabetes · 2020Review
- Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.American journal of physiology. Heart and circulatory physiology · 2019Article
- Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease.Journal of the American College of Cardiology · 2018Article
- Coronary flow reserve is predictive of the risk of cardiovascular death regardless of chronic kidney disease stage.Kidney international · 2018Article
- Incremental role of resting myocardial computed tomography perfusion for predicting physiologically significant coronary artery disease: A machine learning approach.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Diabetic Microvascular Disease: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2017Review
- Coronary calcification compromises myocardial perfusion irrespective of luminal stenosis.International journal of cardiology. Heart & vasculature · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
To define the role of capillaries in the control of coronary blood flow (CBF) reserve, we developed a model of the coronary circulation and evaluated experimental data in its context. Our model comprised three compartments connected in series (arterial, capillary, and venous), each with its own resistance. The resistance in each vascular compartment was derived from the model based on hemodynamic data obtained in nine dogs during baseline and stenosis, both at rest and during hyperemia. The capillary hydrostatic pressure was assumed to be constant in all stages. Although in the absence of stenosis, the contribution of capillaries to total myocardial vascular resistance was only 25 +/- 5% at rest, it increased to 75 +/- 14% during hyperemia, despite the total myocardial vascular resistance decreasing by 51 +/- 13%. In the presence of a noncritical stenosis, total myocardial vascular resistance decreased by 22 +/- 10% at rest, with no change in capillary resistance. During hyperemia, total myocardial vascular resistance increased by 58 +/- 50% in the presence of the noncritical stenosis. In this situation, because arteriolar and venular resistances were already minimal, the increase in myocardial vascular resistance was due to increased capillary resistance, making it the predominant source (84 +/- 8%) of total myocardial vascular resistance. Myocardial video intensity (VI) on myocardial contrast echocardiography (MCE), which reflects capillary blood volume, decreased distal to the stenosis during hyperemia. In the presence of a flow-limiting stenosis at rest, myocardial VI also decreased, indicating that decrease in CBF was associated with an increase in capillary resistance. Our findings also provide an alternative explanation for the critical coronary closing pressure. Thus, contrary to previously held notions, capillaries play a vital role in the regulation of CBF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.