ArticleProceedings of the National Academy of Sciences of the United States of America1999
The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 98 citations in OpenAlex.
- Nuclear organization mediates cancer-compromised genetic and epigenetic control.Advances in biological regulation · 2018Review
- Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation.Leukemia · 2017Article
- An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells.Oncotarget · 2017Article
- Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment.International journal of molecular sciences · 2016Review
- Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.Cell reports · 2014Article
- The dynamic architectural and epigenetic nuclear landscape: developing the genomic almanac of biology and disease.Journal of cellular physiology · 2014Review
- A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation.Experimental hematology · 2013Article
- From blood islands to blood vessels: morphologic observations and expression of key molecules during hyaloid vascular system development.Investigative ophthalmology & visual science · 2012Article
- Bookmarking the genome: maintenance of epigenetic information.The Journal of biological chemistry · 2011Review
- An architectural genetic and epigenetic perspective.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Nup98-homeodomain fusions interact with endogenous Nup98 during interphase and localize to kinetochores and chromosome arms during mitosis.Molecular biology of the cell · 2010Article
- A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.Blood · 2010Article
- Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Human molecular genetics · 2010Article
- Transcription factor-mediated epigenetic regulation of cell growth and phenotype for biological control and cancer.Advances in enzyme regulation · 2010Review
- Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network.Cancer research · 2009Article
- Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes.Journal of cellular physiology · 2009Article
- Transcription-factor-mediated epigenetic control of cell fate and lineage commitment.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2009Review
- Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer.Annals of the New York Academy of Sciences · 2009Article
- The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomes.Journal of cell science · 2008Article
- Genetic and epigenetic regulation in nuclear microenvironments for biological control in cancer.Journal of cellular biochemistry · 2008Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear matrix-targeting signal that directs the AML1 protein to appropriate gene regulatory sites within the nucleus. Here we report that substitution of the chromosome 8-derived ETO protein for the multifunctional C terminus of AML1 precludes targeting of the factor to AML1 subnuclear domains. Instead, the AML1/ETO fusion protein is redirected by the ETO component to alternate nuclear matrix-associated foci. Our results link the ETO chromosomal translocation in AML with modifications in the intranuclear trafficking of the key hematopoietic regulatory factor, AML1. We conclude that misrouting of gene regulatory factors as a consequence of chromosomal translocations is an important characteristic of acute leukemias.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.