ArticleEuropean heart journal2000
Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease.
Article in European heart journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03309618 (Improving Arterial Wall Characteristics in Patients After Myocardial Infarction With a Very Low Dose of Fluvastatin and Valsartan), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Arterial Wall Characteristics in Patients After Myocardial Infarction With a Very Low Dose of Fluvastatin and Valsartan: Proof-of-concept Study
Who cites it
45 citing papers in PubMed, 218 citations in OpenAlex.
- Improving Arterial Wall Characteristics in Patients After Myocardial Infarction with a Very Low Dose of Fluvastatin and Valsartan: A Proof-of-Concept Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- Electric Cell-Substrate Impedance Sensing as a Tool to Characterize Wound Healing Dynamics.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Angiopoietin-like proteins 3, 4 and 8 are linked to cardiovascular function in naïve sub-clinical and overt hypothyroid patients receiving levothyroxine therapy.Endocrine connections · 2021Article
- Remote Ischemic Perconditioning Ameliorates Myocardial Ischemia and Reperfusion-Induced Coronary Endothelial Dysfunction and Aortic Stiffness in Rats.Journal of cardiovascular pharmacology and therapeutics · 2021Article
- The COSEVAST Study Outcome: Evidence of COVID-19 Severity Proportionate to Surge in Arterial Stiffness.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Race and Gender Differences in the Association Between Experiences of Everyday Discrimination and Arterial Stiffness Among Patients With Coronary Heart Disease.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Article
- The effect of cardiac resynchronization therapy on arterial stiffness and central hemodynamic parameters.Journal of arrhythmia · 2020Article
- Highly precise risk prediction model for new-onset hypertension using artificial intelligence techniques.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- In HCV-related liver cirrhosis, local pulse wave velocity increases and in decompensated patients correlates with poorer survival.PloS one · 2019Observational
- Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study.Cardiovascular ultrasound · 2018Article
- The apex of the aortic arch backshifts with aging.Surgical and radiologic anatomy : SRA · 2017Article
- Does aortic pulse wave velocity have any prognostic significance in advanced heart failure patients?Journal of cardiovascular and thoracic research · 2017Article
- Aortic flow propagation velocity, epicardial fat thickness, and osteoprotegerin level to predict subclinical atherosclerosis in patients with nonalcoholic fatty liver disease.Anatolian journal of cardiology · 2016Article
- Inflammation as Possible Mediator for the Relationship Between Lung and Arterial Function.Lung · 2016Article
- Atherosclerotic Renal Artery Stenosis Prevalence and Correlations in Acute Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Interventions: Data From Nonrandomized Single-Center Study (REN-ACS)—A Single Center, Prospective, Observational Study.Journal of the American Heart Association · 2015Observational
- The effect of aortic wall and aortic leaflet stiffening on coronary hemodynamic: a fluid-structure interaction study.Medical & biological engineering & computing · 2013Article
- Aortic Compliance and Stiffness Among Severe Longstanding Hypertensive and Non-hypertensive.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2013Article
- Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep.Pediatric research · 2013Article
- Aortic distensibility and extent and complexity of coronary artery disease in patients with stable hypertensive and nonhypertensive coronary artery disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Article
- Non-invasive measurement of aortic pressure in patients: Comparing pulse wave analysis and applanation tonometry.Indian journal of pharmacology · 2012Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAortic elasticity is an important determinant of left ventricular performance and coronary blood flow. Moreover, it has been shown that aortic elastic properties deteriorate in patients with coronary artery disease. However, the predictive role of aortic elasticity in the occurrence of coronary events, has not been addressed so far. Therefore, we set out to test prospectively the hypothesis that invasive as well as non-invasive measures of aortic elastic properties, assessed at rest from pressure-diameter relationships, could predict the development of recurrent coronary events. METHODS AND
resultsClinical variables and measures of aortic function were assessed in 54 normotensive patients with coronary artery disease. The aortic pressure-diameter relationship was derived invasively with a high-fidelity Y shaped catheter (developed in our Institution) for aortic diameter measurements, simultaneously with a Millar catheter for aortic pressure measurements. Aortic root distensibility was assessed by non-invasive techniques. During an average of 3 years follow-up, 12 of 54 patients either developed unstable angina (n=8) or acute myocardial infarction (n=4). By multivariate Cox model analysis, aortic stiffness was the strongest predictor of progression to any end-point (relative risk: 3.24, CI: 1.79 to 5.83;P=0.000). When aortic stiffness was not considered, aortic distensibility was the only independent predictor for acute coronary syndromes (relative risk: 0.37 CI: 0.21 to 0.65;P=0.000).
conclusionIn patients with coronary artery disease, aortic elastic properties are powerful and independent risk factors for recurrent acute coronary events.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.