Evidence map›Paper›PMID 10700487›Full record

Trial reportStroke2000

Effects of stress reduction on carotid atherosclerosis in hypertensive African Americans.

A Castillo-Richmond, R H Schneider, C N Alexander, R Cook, H Myers, S Nidich, C Haney, M Rainforth, J Salerno

Registry-linked trialOpen access · bronzeAbstract readClinical TrialComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000546 (Stress Reduction and Atherosclerotic CVD in Blacks), which is not on this map. Cited by 60 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 11 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000546 phase3completednot on this map

Stress Reduction and Atherosclerotic CVD in Blacks

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1994 to 2005ConditionsCardiovascular Diseases, Heart Diseases, Hypertension, Vascular DiseasesArmsmeditation
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 11 syntheses or guidelines pooled it, 260 citations in OpenAlex.

  1. Pooled it
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  3. Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials.International journal of environmental research and public health · 2022
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  7. Guideline
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  9. Tai chi for primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2014
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  12. Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography: A pilot study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
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  15. Recreational Music-Making alters gene expression pathways in patients with coronary heart disease.Medical science monitor : international medical journal of experimental and clinical research · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

A Castillo-RichmondCenter for Natural Medicine and Prevention, Maharishi University of Management, College of Maharishi Vedic Medicine, Fairfield, Iowa 52557, USA. amparo@mum.edu
R H Schneider
C N Alexander
R Cook
H Myers
S Nidich
C Haney
M Rainforth
J Salerno
Charles R. Drew University of Medicine and Science · US

Funding

STRESS REDUCTION AND HYPERTENSIVE HEART DISEASER01HL051519 · NHLBI · MAHARISHI UNIVERSITY OF MANAGEMENT · PI SCHNEIDER, ROBERT · 1994 to 2003
$1.5M
NHLBI NIH HHS HL-51519NHLBI NIH HHS HL-51519-S2NHLBI NIH HHS R01 HL051519
6 · The paper itself

Abstract

background and purposeAfrican Americans suffer disproportionately higher cardiovascular disease mortality rates than do whites. Psychosocial stress influences the development and progression of atherosclerosis. Carotid intima-media thickness (IMT) is a valid surrogate measure for coronary atherosclerosis, is a predictor of coronary outcomes and stroke, and is associated with psychosocial stress factors. Stress reduction with the Transcendental Meditation (TM) program decreases coronary heart disease risk factors and cardiovascular mortality in African Americans. B-mode ultrasound is useful for the noninvasive evaluation of carotid atherosclerosis.

methodsThis randomized controlled clinical trial evaluated the effects of the TM program on carotid IMT in hypertensive African American men and women, aged >20 years, over a 6- to 9-month period. From the initially enrolled 138 volunteers, 60 subjects completed pretest and posttest carotid IMT data. The assigned interventions were either the TM program or a health education group. By use of B-mode ultrasound, mean maximum IMT from 6 carotid segments was used to determine pretest and posttest IMT values. Regression analysis and ANCOVA were performed.

resultsAge and pretest IMT were found to be predictors of posttest IMT values and were used as covariates. The TM group showed a significant decrease of -0.098 mm (95% CI -0. 198 to 0.003 mm) compared with an increase of 0.054 mm (95% CI -0.05 to 0.158 mm) in the control group (P=0.038, 2-tailed).

conclusionsStress reduction with the TM program is associated with reduced carotid atherosclerosis compared with health education in hypertensive African Americans. Further research with this stress-reduction technique is warranted to confirm these preliminary findings.

Indexed as

Black PeopleMeditationBlack or African AmericanCarotid Artery DiseasesDisease ProgressionFemaleHealth EducationHumansHypertensionMaleStress, PsychologicalUltrasonography

Identifiers

PMID10700487
PMCPMC9341385
OpenAlexW2136404227

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.