Evidence mapPaperPMID 10702749Full record

ArticleInternational journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity2000

Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies.

A Flint, A Raben, J E Blundell, A Astrup

19 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 19 registered trials, which are not on this map. Cited by 789 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
789citing papers in PubMed, 4 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01795248 phase4completedstarted 2012, after this paper: background citation

The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Gestational Diabetes Mellitus

Ran2012Enrolled105Registered outcomes18Posted comparisons0ConditionsGestational Diabetes MellitusArmsliraglutide, Placebo
Open the trial in the graph
NCT00659165 nacompletednot on this mapstarted 2008, after this paper: background citation

Exploration of the Weight Neutral Effects of Insulin Detemir Compared to Insulin Glargine: A Measure of Satiety and Calories Consumed in Type 1 Diabetes

TypeinterventionalSponsorUniversity of New MexicoRan2008 to 2011Enrolled10ConditionsDiabetes MellitusArmsInsulin Detemir, Insulin Glargine
NCT01990560 phase4completednot on this mapstarted 2013, after this paper: background citation

Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2013 to 2016Enrolled8ConditionsMild HypercortisolismArmsMifepristone
NCT02929849 nacompletednot on this mapstarted 2015, after this paper: background citation

Influence of Herb With Alpha-glucosidase Properties (Salacia Chinensis) on Appetite, Glucose and Hormonal Factors: A Double Blind Randomized Placebo Controlled-crossover Trial

TypeinterventionalSponsorRutgers UniversityRan2015 to 2017Enrolled51ConditionsObesityArms300 mg SC, 500 mg SC, Placebo
NCT02932046 completednot on this mapstarted 2014, after this paper: background citation

Hunger and Satiety Perception in Patients With Anorexia Nervosa

TypeobservationalSponsorOdense University HospitalRan2014 to 2016Enrolled47ConditionsAnorexia Nervosa, Appetite DisordersArmsStandardized noon meal
NCT02982616 nacompletednot on this mapstarted 2015, after this paper: background citation

Influence of Intragastric Fatty Acid Infusion on Behavioral Responses to Positive Emotion Induction in Normal Weight Subjects

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2015 to 2016Enrolled12ConditionsHealthy VolunteersArmsDodecanoic acid, Positive emotion, saline, neutral emotion
NCT04075448 nacompletednot on this mapstarted 2019, after this paper: background citation

The Acute Effect of a Walnut Intervention on Cognitive Performance , Brain Activation, and Serum Markers of Inflammation in Young Adults

TypeinterventionalSponsorUniversity of ReadingRan2019 to 2020Enrolled32ConditionsCognitive Change, Mood, Inflammatory Response, Brain Derived Neurotrophic Factor LevelArmsControl, 50 g Walnut
NCT04306445 naterminatednot on this mapstarted 2020, after this paper: background citation

The Effect of a Gas-filled Intragastric Balloon or Endoscopic Sleeve Gastroplasty for Weight Loss Compared With a Meal Replacement Weight Loss Program on Gastric Emptying, Hormonal Adaptation to Weight Loss, and Hunger

TypeinterventionalSponsorUniversity of Colorado, DenverRan2020 to 2024Enrolled3ConditionsObesityArmsGF-IGB: Obalon Balloon, Medically Supervised Meal Replacement Program: My New Weigh, Endoscopic sleeve gastroplasty: (ESG)
NCT04487678 nawithdrawnnot on this mapstarted 2023, after this paper: background citation

A Single-centre, Randomised, Single-blinded Crossover Study Evaluating the Metabolic Effects of a Ketone Ester Food Supplement in People With Type 1 Diabetes

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2023 to 2023Enrolled0ConditionsKetosis, DiabeticArmsKetone ester supplement
NCT05616052 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

Prospective Randomized Controlled Study on the Improvement of Body Weight Among Overweight and Obese Patients Through Different Smeglutide Administration Methods

TypeinterventionalSponsorHuashan HospitalRan2022 to 2023Enrolled80ConditionsWeight Change, BodyArmsSemaglutide
NCT06096233 narecruitingnot on this mapstarted 2023, after this paper: background citation

Acute Effect of Exercise on Post-meal Appetite, Appetite-Regulatory Hormones, and Energy Intake in Healthy Men

TypeinterventionalSponsorUniversity of GlasgowRan2023 to 2026Enrolled14ConditionsHealthyArmsBouts of Exercise
NCT06839248 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Fasting Recommendations on Residual Gastric Contents Among Patients Using Glucagon-like Peptide-1 Receptor Agonists: A Randomised Controlled Trial

TypeinterventionalSponsorSt Vincent's Hospital MelbourneRan2025 to 2027Enrolled154ConditionsResidual Gastric Contents, Pulmonary Aspiration of Gastric ContentsArms24-hour clear liquid diet, Standard fasting guidelines
NCT06895837 narecruitingnot on this mapstarted 2025, after this paper: background citation

Acute Effect of Exercise on Appetite, Appetite-Regulatory Hormones, and Energy Intake During Energy Restriction in Healthy Men

TypeinterventionalSponsorUniversity of GlasgowRan2025 to 2028Enrolled14ConditionsHealthyArmsSevere-energy restriction, Severe-energy restriction with exercise
NCT06916039 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Randomized Controlled Nutrition Trial on Breakfast Glycaemic Index on the Course of Memory and Attention Among Young Adults - Relevance of Chronotype

TypeinterventionalSponsorAnette BuykenRan2025 to 2027Enrolled177ConditionsHealthyArmsimmediate verbal memory after high GI breakfast, immediate verbal memory after low glycemic index breakfast
NCT06941740 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Randomized Controlled Nutrition Trial on Reactive Hypoglycaemia on the Course of Memory and Attention Among Young Adults - Relevance of Chronotype

TypeinterventionalSponsorAnette BuykenRan2025 to 2027Enrolled177ConditionsHealthyArmsimmediate verbal memory after low glycemic index breakfast inducing no reactive hypoglycaemia, immediate verbal memory after low glycemic index breakfast causing reactive hypoglycaemia
NCT07262593 naterminatednot on this mapstarted 2024, after this paper: background citation

Family-Based Meal Timing for Cancer Prevention Among Native Hawaiian and Other Pacific Islanders: FAMTIME

TypeinterventionalSponsorUniversity of UtahRan2024 to 2024Enrolled2ConditionsCancer PreventionArmsTime Restricted Eating (TRE), Medically Tailored Meals (MTM)
NCT07387796 narecruitingnot on this mapstarted 2026, after this paper: background citation

Clinical and Neurobehavioral Changes With GLP-1 (Glucagon-like Peptide-1) Discontinuation

TypeinterventionalSponsorThe University of Texas at DallasRan2026 to 2029Enrolled40ConditionsDrug Discontinuation, Substance Use Disorders, Eating Behavior Changes, TirzepatideArmsDiscontinuation and Reinitiation of Tirzepatide
NCT07776418 narecruitingnot on this mapstarted 2026, after this paper: background citation

The ZOE SMART EATS (Satiety, Microbiome, Appetite Regulation, and Tracking Energy Across Targeted Snacks) Acute Postprandial Study: Investigating the Acute Effects of a High-fibre Plant-based Snack Bar on Subjective Postprandial Hunger, Energy Intake and Eating Behaviour in Healthy UK Adults.

TypeinterventionalSponsorZoe Global LimitedRan2026 to 2026Enrolled54ConditionsHealthy Participants, Healthy Adult Subject, Healthy Subjects, Healthy Adult VolunteerArmsHigh-fibre plant-based snack bar, Control snack bars
NCT07782593 narecruitingnot on this mapstarted 2026, after this paper: background citation

The ZOE SMART EATS (Satiety, Microbiome, Appetite Regulation, and Tracking Energy Across Targeted Snacks) Chronic Randomised Controlled Trial: Investigating the Chronic Effects of a High-fibre Plant-based Snack Bar on Subjective Daily Hunger, the Gut Microbiome and Gastrointestinal Symptoms in Healthy UK Adults.

TypeinterventionalSponsorZoe Global LimitedRan2026 to 2026Enrolled100ConditionsHealthy Participants, Healthy Adult Subject, Healthy Subjects, Healthy Adult VolunteerArmsHigh-fibre plant-based snack bar, Control snack bars
3 · Its place in the literature

Who cites it

789 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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729 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A FlintResearch Department of Human Nutrition, Center for Food Research, The Royal Veterinary and Agricultural University, DK-1958 Frederiksberg C, Denmark. afl@kvl.dk
A Raben
J E Blundell
A Astrup

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine reproducibility and validity of visual analogue scales (VAS) for measurement of appetite sensations, with and without a diet standardization prior to the test days.

designOn two different test days the subjects recorded their appetite sensations before breakfast and every 30 min during the 4.5 h postprandial period under exactly the same conditions. SUBJECTS: 55 healthy men (age 25.6+/-0.6 y, BMI 22.6+/-0.3 kg¿m2). MEASUREMENTS: VAS were used to record hunger, satiety, fullness, prospective food consumption, desire to eat something fatty, salty, sweet or savoury, and palatability of the meals. Subsequently an ad libitum lunch was served and energy intake was recorded. Reproducibility was assessed by the coefficient of repeatability (CR) of fasting, mean 4.5 h and peak/nadir values.

resultsCRs (range 20-61 mm) were larger for fasting and peak/nadir values compared with mean 4.5 h values. No parameter seemed to be improved by diet standardization. Using a paired design and a study power of 0.8, a difference of 10 mm on fasting and 5 mm on mean 4.5 h ratings can be detected with 18 subjects. When using desires to eat specific types of food or an unpaired design, more subjects are needed due to considerable variation. The best correlations of validity were found between 4.5 h mean VAS of the appetite parameters and subsequent energy intake (r=+/-0.50-0.53, P<0.001).

conclusionVAS scores are reliable for appetite research and do not seem to be influenced by prior diet standardization. However, consideration should be given to the specific parameters being measured, their sensitivity and study power. International Journal of Obesity (2000)24, 38-48

Indexed as

AppetiteAdultAnalysis of VarianceHumansHungerMalePain MeasurementPostprandial PeriodReproducibility of ResultsSatiationSurveys and QuestionnairesTaste

Identifiers

PMID10702749

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

and 13 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.