ArticleBiochemical pharmacology2000
Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestine.
Article in Biochemical pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04841668 (Gut-Brain-axis), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review.Diabetologia · 2006Pooled it
- Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study.Diabetologia · 2019Trial
- Clearance of the high intestinal (18)F-FDG uptake associated with metformin after stopping the drug.European journal of nuclear medicine and molecular imaging · 2010Trial
- Reframing metformin as a gut-targeted glucose-lowering therapy: Mechanistic insights and translational relevance.Molecular metabolism · 2025Article
- New Perspectives on the Molecular Action of Metformin in the Context of Cellular Transduction and Adipogenesis.International journal of molecular sciences · 2025Review
- The Gut Microbiota-Related Antihyperglycemic Effect of Metformin.Pharmaceuticals (Basel, Switzerland) · 2025Review
- An antifibrotic compound that ameliorates hyperglycaemia and fat accumulation in cell and HFD mouse models.Diabetologia · 2024Article
- Host or the Hosted? Effects of Non-Nutritive Sweeteners on Intestinal and Microbial Mechanisms of Glycemic Control.Nutrients · 2024Article
- Understanding the action mechanisms of metformin in the gastrointestinal tract.Frontiers in pharmacology · 2024Review
- Metformin: update on mechanisms of action and repurposing potential.Nature reviews. Endocrinology · 2023Review
- Article
- Metformin action in the gut-insight provided by [Diabetology international · 2022Article
- Metformin treatment for 8 days impacts multiple intestinal parameters in high-fat high-sucrose fed mice.Scientific reports · 2021Article
- Meta-Assessment of Metformin Absorption and Disposition Pharmacokinetics in Nine Species.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Cucurbitacin B Suppresses Hyperglycemia Associated with a High Sugar Diet and Promotes Sleep inMolecules and cells · 2021Article
- A Review of Coumarins and Coumarin-Related Compounds for Their Potential Antidiabetic Effect.Clinical medicine insights. Endocrinology and diabetes · 2021Review
- Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of Metformin.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours.British journal of pharmacology · 2019Article
- Effects of insulin and metformin on fetal kidney development of streptozotocin-induced gestational diabetic albino rats.Anatomy & cell biology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the effect of metformin on intestinal glucose absorption, a perfusion study of the intestine was performed in the rat. Male Wistar albino rats (8 weeks old) were used in the present study. The glucose absorption by the perfused intestine (788.1+/-81.9 micromol/30 min) was not changed significantly by the direct addition of metformin (90 microg/mL) to the perfusing medium (737.0+/-118.2 micromol/30 min) or by intraduodenal metformin (250 mg/kg in saline solution) infusion (772.8+/-106.3 micromol/30 min). In rats orally administered metformin (250 mg/kg) for 5 days, glucose absorption by the perfused intestine (375.0+/-164.3 micromol/30 min) was significantly (P<0.001) lower than that in control rats (811.0+/-83.1 micromol/30 min). These results indicate that metformin had a significant effect on the digestive tract, and that metformin treatment exerted an inhibitory effect on intestinal glucose absorption in the rat.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.