ReviewThe Journal of clinical investigation2000
Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.
Review in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01589445 (Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.), which is not on this map. Cited by 143 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modulation of Insulin Secretion and Insulin Sensitivity in Bangladeshi Type 2 Diabetic Subjects by an Insulin Sensitizer Pioglitazone and T2DM Association With PPARG Gene Polymorphism.
Who cites it
143 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus.Endocrine · 2016Pooled it
- Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review.Diabetologia · 2006Pooled it
- Impact of pioglitazone on bone mineral density and bone marrow fat content.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Trial
- Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization.Proceedings of the National Academy of Sciences of the United States of America · 2009Trial
- Pan-Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Secondary Lymphedema via Inhibiting TGFβ/SMAD2/3 Signaling Pathway.bioRxiv : the preprint server for biology · 2026Article
- Impact of Sex on the Therapeutic Efficacy of Rosiglitazone in Modulating White Adipose Tissue Function and Insulin Sensitivity.Nutrients · 2024Article
- Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation.Fluids and barriers of the CNS · 2024Article
- Article
- IRW (Isoleucine-Arginine-Tryptophan) Improves Glucose Tolerance in High Fat Diet Fed C57BL/6 Mice via Activation of Insulin Signaling and AMPK Pathways in Skeletal Muscle.Biomedicines · 2022Article
- Inonotus obliquus polysaccharide ameliorates serum profiling in STZ-induced diabetic mice model.BMC chemistry · 2021Article
- Efficacy of Ninjin'yoeito in treating severe coronavirus disease 2019 in patients in an intensive care unit.Neuropeptides · 2021Article
- Review
- Development and validation of a sensitive LC-MS/MS method for pioglitazone: application towards pharmacokinetic and tissue distribution study in rats.RSC advances · 2021Article
- Review
- Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues.Frontiers in cell and developmental biology · 2021Review
- Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Review
- A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities.Journal of medicinal chemistry · 2020Article
- The Role of PPARδ Agosnist GW501516 in Rats with Gestational Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- GVS-12 attenuates non-alcoholic steatohepatitis by suppressing inflammatory responsesRSC advances · 2019Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.