SynthesisBMJ (Clinical research ed.)2000
Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. Dyspepsia Review Group.
Synthesis in BMJ (Clinical research ed.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 7 syntheses or guidelines pooled it, 369 citations in OpenAlex.
- Guideline
- The Association betweenInternational journal of environmental research and public health · 2020Pooled it
- Effectiveness of management strategies for uninvestigated dyspepsia: systematic review and network meta-analysis.BMJ (Clinical research ed.) · 2019Pooled it
- ACG and CAG Clinical Guideline: Management of Dyspepsia.The American journal of gastroenterology · 2017Guideline
- Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis.World journal of gastroenterology · 2016Pooled it
- Optimum duration of regimens for Helicobacter pylori eradication.The Cochrane database of systematic reviews · 2013Pooled it
- Adverse events with bismuth salts for Helicobacter pylori eradication: systematic review and meta-analysis.World journal of gastroenterology · 2008Pooled it
- Proton pump inhibitors: effective first-line treatment for management of dyspepsia.Digestive diseases and sciences · 2007Trial
- Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial.BMJ (Clinical research ed.) · 2006Trial
- Trial
- Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment-Helicobacter pylori positive (CADET-Hp) randomised controlled trial.BMJ (Clinical research ed.) · 2002Trial
- Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsia.BMJ (Clinical research ed.) · 2002Trial
- A randomised controlled trial of four management strategies for dyspepsia: relationships between symptom subgroups and strategy outcome.The British journal of general practice : the journal of the Royal College of General Practitioners · 2001Trial
- Randomised controlled trial of Helicobacter pylori testing and endoscopy for dyspepsia in primary care.BMJ (Clinical research ed.) · 2001Trial
- Role of Endoscopy in Motility Disorders of Upper Gastrointestinal Tract.Journal of neurogastroenterology and motility · 2023Review
- Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer.Scientific reports · 2020Article
- Thailand Dyspepsia Guidelines: 2018.Journal of neurogastroenterology and motility · 2019Review
- Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis.Archives of medical science : AMS · 2019Review
- Prevalence ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Population screening and treatment of Helicobacter pylori infection.Nature reviews. Gastroenterology & hepatology · 2017Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate efficacy and cost effectiveness of Helicobacter pylori eradication treatment in patients with non-ulcer dyspepsia infected with H pylori.
designSystematic review of randomised controlled trials comparing H pylori eradication with placebo or another drug treatment. Results were incorporated into a Markov model comparing health service costs and benefits of H pylori eradication with antacid treatment over one year. DATA SOURCES: Six electronic databases were searched for randomised controlled trials from January 1966 to May 2000. Experts in the field, pharmaceutical companies, and journals were contacted for information on any unpublished trials. Trial reports were reviewed according to predefined eligibility and quality criteria.
main outcome measuresRelative risk reduction for remaining dyspeptic symptoms (the same or worse) at 3-12 months. Cost per dyspepsia-free month estimated from Markov model based on estimated relative risk reduction.
resultsTwelve trials were included in the systematic review, nine of which evaluated dyspepsia at 3-12 months in 2541 patients. H pylori eradication treatment was significantly superior to placebo in treating non-ulcer dyspepsia (relative risk reduction 9% (95% confidence interval 4% to 14%)), one case of dyspepsia being cured for every 15 people treated. H pylori eradication cost pound56 per dyspepsia-free month during first year after treatment.
conclusionH pylori eradication may be cost effective treatment for non-ulcer dyspepsia in infected patients but further evidence is needed on decision makers' willingness to pay for relief of dyspepsia.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.