ArticleThe EMBO journal2000
SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 83 citations in OpenAlex.
- Neuroprotection and activation of anti-inflammatory and plasticity mechanisms by PLC-β inhibition after cholinergic hyperstimulation in hippocampal slices and microglial cells.IBRO neuroscience reports · 2025Article
- Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa-induced dyskinesia in a mouse model of Parkinson's disease.Gene therapy · 2024Article
- TYMS Knockdown Suppresses Cells Proliferation, Promotes Ferroptosis via Inhibits PI3K/Akt/mTOR Signaling Pathway Activation in Triple Negative Breast Cancer.Cell biochemistry and biophysics · 2024Article
- Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties.Archives of pharmacal research · 2023Article
- AR-mTOR-SRF Axis Regulates HMMR Expression in Human Prostate Cancer Cells.Biomolecules & therapeutics · 2021Article
- Myopalladin promotes muscle growth through modulation of the serum response factor pathway.Journal of cachexia, sarcopenia and muscle · 2020Article
- Suppression of the ERK-SRF axis facilitates somatic cell reprogramming.Experimental & molecular medicine · 2018Article
- The impact of Mir-9 regulation in normal and malignant hematopoiesis.Oncology reviews · 2018Article
- Mutations in ARID2 are associated with intellectual disabilities.Neurogenetics · 2015Article
- Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway.Molecular and cellular biology · 2013Article
- Myocardin-related transcription factor-A complexes activate type I collagen expression in lung fibroblasts.The Journal of biological chemistry · 2011Article
- Article
- Serum response factor regulates immediate early host gene expression in Toxoplasma gondii-infected host cells.PloS one · 2011Article
- Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium.BMC developmental biology · 2011Article
- Identification of New SRF Binding Sites in Genes Modulated by SRF Over-Expression in Mouse Hearts.Gene regulation and systems biology · 2011Article
- GREAT improves functional interpretation of cis-regulatory regions.Nature biotechnology · 2010Article
- TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.Journal of the American Society of Nephrology : JASN · 2009Article
- Treatment of injured neurons with bone marrow stem cells cotransfected by hTERT and Ad-BDNF in vitro.Journal of molecular neuroscience : MN · 2009Article
- The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.Nature genetics · 2009Article
- Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice.Hepatology (Baltimore, Md.) · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence indicates that phosphatidylinositol 3-kinase (PI3K) is a central regulator of mitosis, apoptosis and oncogenesis. Nevertheless, the mechanisms by which PI3K regulates proliferation are not well characterized. Mitogens stimulate entry into the cell cycle by inducing the expression of immediate early genes (IEGs) that in turn trigger the expression of G(1) cyclins. Here we describe a novel PI3K- regulated transcriptional cascade that is critical for mitogen regulation of the IEG, c-fos. We show that PI3K activates gene expression by transactivating SRF-dependent transcription independently of the previously described Rho and ETS TCF pathways. PI3K-stimulated cell cycle progression requires transactivation of SRF and expression of dominant- negative PI3K blocks mitogen-stimulated cell cycle progression. Furthermore, dominant-interfering SRF mutants attenuate mitogen-stimulated cell cycle progression, but are without effect on MEK-stimulated cell cycle entry. Moreover, expression of constitutively active SRF is sufficient for cell cycle entry. Thus, we delineate a novel SRF-dependent mitogenic cascade that is critical for PI3K- and growth factor-mediated cell cycle progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.