ArticleAnnals of surgery2000
Simultaneous cadaver pancreas living-donor kidney transplantation: a new approach for the type 1 diabetic uremic patient.
Article in Annals of surgery, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 110 citations in OpenAlex.
- Transplant Options for Patients With Diabetes and Advanced Kidney Disease: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Review
- Solid pancreas transplant: Pushing forward.World journal of transplantation · 2018Review
- Advances in pancreas transplantation.Journal of the Royal Society of Medicine · 2016Review
- Imaging in pancreatic transplants.The Indian journal of radiology & imaging · 2014Article
- Pancreatic transplantation: surgical technique, normal radiological appearances and complications.Insights into imaging · 2010Article
- Pancreas transplantation.Annals of the Royal College of Surgeons of England · 2008Review
- A decade of experience with renal transplantation in African-Americans.Annals of surgery · 2002Article
- Pancreas and kidney transplantation.Current diabetes reports · 2002Review
- Superiority of portal venous drainage over systemic venous drainage in pancreas transplantation: a retrospective study.Annals of surgery · 2001Article
- Lessons learned from more than 1,000 pancreas transplants at a single institution.Annals of surgery · 2001Review
- Increased rates of donation with laparoscopic donor nephrectomy.Annals of surgery · 2000Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the authors' experience with a new approach for type I diabetic uremic patients: simultaneous cadaver-donor pancreas and living-donor kidney transplant (SPLK). SUMMARY BACKGROUND DATA: Simultaneous cadaver kidney and pancreas transplantation (SPK) and living-donor kidney transplantation alone followed by a solitary cadaver-donor pancreas transplant (PAK) have been the transplant options for type I diabetic uremic patients. SPK pancreas graft survival has historically exceeded that of solitary pancreas transplantation. Recent improvement in solitary pancreas transplant survival rates has narrowed the advantage seen with SPK. PAK, however, requires sequential transplant operations. In contrast to PAK and SPK, SPLK is a single operation that offers the potential benefits of living kidney donation: shorter waiting time, expansion of the organ donor pool, and improved short-term and long-term renal graft function.
methodsBetween May 1998 and September 1999, the authors performed 30 SPLK procedures, coordinating the cadaver pancreas transplant with simultaneous transplantation of a laparoscopically removed living-donor kidney. Of the 30 SPLKs, 28 (93%) were portally and enterically drained. During the same period, the authors also performed 19 primary SPK and 17 primary PAK transplants.
resultsOne-year pancreas, kidney, and patient survival rates were 88%, 95%, and 95% for SPLK recipients. One-year pancreas graft survival rates in SPK and PAK recipients were 84% and 71%. Of 30 SPLK transplants, 29 (97%) had immediate renal graft function, whereas 79% of SPK kidneys had immediate function. Reoperative rates, early readmission to the hospital, and initial length of stay were similar between SPLK and SPK recipients. SPLK recipients had a shorter wait time for transplantation.
conclusionsEarly pancreas, kidney, and patient survival rates after SPLK are similar to those for SPK. Waiting time was significantly shortened. SPLK recipients had lower rates of delayed renal graft function than SPK recipients. Combining cadaver pancreas transplantation with living-donor kidney transplantation does not harm renal graft outcome. Given the advantages of living-donor kidney transplant, SPLK should be considered for all uremic type I diabetic patients with living donors.
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