ArticleProceedings of the National Academy of Sciences of the United States of America2000
TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Transcriptome Analysis Reveals the Function of a G-Protein α Subunit Gene in the Growth and Development ofJournal of fungi (Basel, Switzerland) · 2023Article
- Alternative Splicing ofFrontiers in microbiology · 2021Article
- Involvement of the Mitochondrial Protein Tyrosine Phosphatase PTPM1 in the Promotion of Conidiation, Development, and Pathogenicity inFrontiers in microbiology · 2020Article
- Integrins in disguise - mechanosensors inMicrobial cell (Graz, Austria) · 2019Review
- A clinical study on the expression of PTEN in renal cell carcinoma in children.Oncology letters · 2019Article
- Deletion ofJournal of fungi (Basel, Switzerland) · 2018Article
- High-resolution profiling of stationary-phase survival reveals yeast longevity factors and their genetic interactions.PLoS genetics · 2014Article
- Phosphoinositides: tiny lipids with giant impact on cell regulation.Physiological reviews · 2013Review
- A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics.Molecular cancer · 2010Article
- FgTep1p is linked to the phosphatidylinositol-3 kinase signalling pathway and plays a role in the virulence of Fusarium graminearum on wheat.Molecular plant pathology · 2010Article
- Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.Oncogene · 2008Review
- Ascospore formation in the yeast Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2005Review
- Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.The Biochemical journal · 2005Article
- Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.The Journal of cell biology · 2004Article
- Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
PTEN/MMAC1/TEP1 (PTEN, phosphatase deleted on chromosome ten; MMAC1, mutated in multiple advanced cancers; TEP1, tensin-like phosphatase) is a major human tumor suppressor gene whose suppressive activity operates on the phosphatidylinositol pathway. A single homologue of this gene, TEP1 (YNL128w), exists in the budding yeast Saccharomyces cerevisiae. Yeast strains deleted for TEP1 exhibit essentially no phenotype in haploids; however, diploids exhibit resistance to the phosphatidylinositol-3-phosphate kinase inhibitor wortmannin and to lithium ions. Although rates of cancer increase with age, neither tep1 haploids nor diploids have altered life spans. TEP1 RNA is present throughout the cell cycle, and levels are dramatically up-regulated during meiotic development. Although homozygous tep1 mutants initiate the meiotic program and form spores with wild-type kinetics, analysis of the spores produced in tep1 mutants indicates a specific defect in the trafficking or deposition of dityrosine, a major component of yeast spore walls, to the surface. Introduction of a common PTEN mutation found in human tumors into the analogous position in Tep1p produces a nonfunctional protein based on in vivo activity. These studies implicate Tep1p in a specific developmental trafficking or deposition event and suggest that Tep1p, like its mammalian counterpart, impinges on the phosphatidylinositol pathway.
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