ArticleMolecular and cellular biology2001
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling.
Article in Molecular and cellular biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Impact of deleterious missense PRKCI variants on structural and functional dynamics of protein.Scientific reports · 2022Article
- PKCζ facilitates lymphatic metastatic spread of prostate cancer cells in a mice xenograft model.Oncogene · 2019Article
- A kinome-wide high-content siRNA screen identifies MEK5-ERK5 signaling as critical for breast cancer cell EMT and metastasis.Oncogene · 2018Article
- Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector.The Journal of biological chemistry · 2016Article
- Transcriptome-wide functional characterization reveals novel relationships among differentially expressed transcripts in developing soybean embryos.BMC genomics · 2015Article
- Article
- ERK5 Mediated Signalling in Diabetic Retinopathy.Medical hypothesis, discovery & innovation ophthalmology journal · 2015Review
- Characterization of tumor differentiation factor (TDF) and its receptor (TDF-R).Cellular and molecular life sciences : CMLS · 2013Review
- Article
- Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling.Biology open · 2012Article
- Article
- Cytoskeletal protein kinases: titin and its relations in mechanosensing.Pflugers Archiv : European journal of physiology · 2011Review
- Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.The Journal of biological chemistry · 2011Article
- The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages.PloS one · 2011Article
- Quantitative automated microscopy (QuAM) elucidates growth factor specific signalling in pain sensitization.Molecular pain · 2010Article
- Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.The Journal of biological chemistry · 2010Article
- G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).The Journal of biological chemistry · 2010Article
- Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells.Journal of cellular physiology · 2009Article
- Activation of ERK5 in angiotensin II-induced hypertrophy of human aortic smooth muscle cells.Molecular and cellular biochemistry · 2009Article
- Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).Molecular cancer therapeutics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MEK5-extracellular signal-regulated kinase (ERK5) tandem is a novel mitogen-activated protein kinase cassette critically involved in mitogenic activation by the epidermal growth factor (EGF). The atypical protein kinase C isoforms (aPKCs) have been shown to be required for cell growth and proliferation and have been reported to interact with the adapter protein p62 through a short stretch of acidic amino acids termed the aPKC interaction domain. This region is also present in MEK5, suggesting that it may be an aPKC-binding partner. Here we demonstrate that the aPKCs interact in an EGF-inducible manner with MEK5 and that this interaction is required and sufficient for the activation of MEK5 in response to EGF. Consistent with the role of the aPKCs in the MEK5-ERK5 pathway, we show that zetaPKC and lambda/iotaPKC activate the Jun promoter through the MEF2C element, a well-established target of ERK5. From all these results, we conclude that MEK5 is a critical target of the aPKCs during mitogenic signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.