ArticleCirculation2001
Role of variability in microvascular resistance on fractional flow reserve and coronary blood flow velocity reserve in intermediate coronary lesions.
Article in Circulation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of the Antidiabetic Drug DAPAgliflozin on the Coronary Macrovascular and MICROvascular Function in Type 2 Diabetic Patients
FFR Versus iFR in Assessment of Hemodynamic Lesion Significance Using Gene Polymorphisms and Lesion Morphology Assessed by OCT (FiGARO Trial)
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it, 263 citations in OpenAlex.
- Angiography-based coronary microvascular assessment with and without intracoronary pressure measurements: a systematic review.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Pooled it
- Intracoronary physiological indices for coronary microvascular dysfunction: from concept to clinical application.Cardiovascular intervention and therapeutics · 2026Review
- Article
- Coronary microvascular dysfunction: pathophysiology, diagnosis, and therapeutic strategies across cardiovascular diseases.EXCLI journal · 2025Review
- Ability of the coronary angiography-derived index of microcirculatory resistance to predict microvascular obstruction in patients with ST-segment elevation.Frontiers in cardiovascular medicine · 2024Article
- Coronary microvascular resistance comparison of coronary arteries with and without considering vascular diameter: A retrospective, single-center study.Health science reports · 2023Article
- Invasive Coronary Assessment in Myocardial Ischemia with No Obstructive Coronary Arteries.Current atherosclerosis reports · 2023Review
- Characterization and implications of intracoronary hemodynamic assessment during coronary spasm provocation testing.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Prospects for Precision Medicine in Acute Myocardial Infarction: Patient-Level Insights into Myocardial Injury and Repair.Journal of clinical medicine · 2023Review
- The Controversies of Coronary Artery Disease in End-Stage Kidney Disease Patients: A Narrative Review.Reviews in cardiovascular medicine · 2023Review
- Particularities of coronary physiology in patients with atrial fibrillation: insights from combined pressure and flow indices measurements.Frontiers in cardiovascular medicine · 2023Article
- Invasive Detection of Coronary Microvascular Dysfunction: How It Began, and Where We Are Now.Interventional cardiology (London, England) · 2023Review
- Three-Dimensional Angiographic Characteristics versus Functional Stenosis Severity in Fractional and Coronary Flow Reserve Discordance: A DEFINE FLOW Sub Study.Diagnostics (Basel, Switzerland) · 2022Article
- The Complementary Value of Absolute Coronary Flow in the Assessment of Patients with Ischaemic Heart Disease (the COMPAC-Flow Study).Nature cardiovascular research · 2022Article
- Heart Team risk assessment with angiography-derived fractional flow reserve determining the optimal revascularization strategy in patients with multivessel disease: Trial design and rationale for the DECISION QFR randomized trial.Clinical cardiology · 2022Article
- Comparison of Doppler Flow Velocity and Thermodilution Derived Indexes of Coronary Physiology.JACC. Cardiovascular interventions · 2022Article
- Coronary Physiology: Delivering Precision Medicine?Reviews in cardiovascular medicine · 2022Review
- Invasive Diagnosis of Coronary Functional Disorders Causing Angina Pectoris.European cardiology · 2021Review
- Physiology-Based Revascularization of Left Main Coronary Artery Disease.Journal of interventional cardiology · 2021Review
- Invasive coronary physiology: a Dutch tradition.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFractional flow reserve (FFR) and coronary blood flow velocity reserve (CFR) represent physiological quantities used to evaluate coronary lesion severity and to make clinical decisions. A comparison between the outcomes of both diagnostic techniques has not been performed in a large cohort of patients with intermediate coronary lesions. METHODS AND
resultsFFR and CFR were assessed in 126 consecutive patients with 150 intermediate coronary lesions (between 40% and 70% diameter stenosis by visual assessment). Agreement between outcomes of FFR and CFR, categorized at cut-off values of 0.75 and 2.0, respectively, was observed in 109 coronary lesions (73%), whereas discordant outcomes were present in 41 lesions (27%). In 26 of these 41 lesions, FFR was <0.75 and CFR>or=2.0 (group A); in the remaining 15 lesions, FFR was >or=0.75 and CFR<2.0 (group B). Minimum microvascular resistance, defined as the ratio of mean distal pressure to average peak blood flow velocity during maximum hyperemia, showed a large variability (overall range, 0.65 to 4.64 mm Hg x cm(-1) x s(-1)) and was significantly higher in group B than in group A (2.42+/-0.77 versus 1.91+/-0.70 mm Hg x cm(-1) x s(-1); P:=0.034).
conclusionsOur findings demonstrate the prominent role of microvascular resistance in modulating the relationship between FFR and CFR and emphasize the importance of combined pressure and flow velocity measurements to evaluate coronary lesion severity and microvascular involvement.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.