ArticleThe Journal of cell biology2001
Distinct regions in the 3' untranslated region are responsible for targeting and stabilizing utrophin transcripts in skeletal muscle cells.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- CRISPR-Cas9-mediated upregulation of utrophin ameliorates Duchenne muscular dystrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Anisomycin Activates Utrophin Upregulation Through a p38 Signaling Pathway.Clinical and translational science · 2018Article
- Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.The Journal of physiology · 2016Article
- Combinatorial therapeutic activation with heparin and AICAR stimulates additive effects on utrophin A expression in dystrophic muscles.Human molecular genetics · 2016Article
- Conserved regions of the DMD 3' UTR regulate translation and mRNA abundance in cultured myotubes.Neuromuscular disorders : NMD · 2014Article
- Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle.Nucleic acids research · 2014Article
- Tumor suppression by RNA from C/EBPβ 3'UTR through the inhibition of protein kinase Cε activity.PloS one · 2011Article
- Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.PloS one · 2011Article
- In vivo monitoring of mRNA movement in Drosophila body wall muscle cells reveals the presence of myofiber domains.PloS one · 2009Article
- Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs.PloS one · 2009Article
- MicroRNA-206: the skeletal muscle-specific myomiR.Biochimica et biophysica acta · 2008Review
- Modulation of utrophin A mRNA stability in fast versus slow muscles via an AU-rich element and calcineurin signaling.Nucleic acids research · 2008Article
- Viral-mediated gene therapy for the muscular dystrophies: successes, limitations and recent advances.Biochimica et biophysica acta · 2007Review
- The Arabidopsis cytoskeletal genome.The arabidopsis book · 2003Article
- Targeted trafficking of neurotransmitter receptors to synaptic sites.Molecular neurobiology · 2002Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In this study, we have sought to determine whether utrophin transcripts are targeted to a distinct subcellular compartment in skeletal muscle cells, and have examined the role of the 3' untranslated region (UTR) in regulating the stability and localization of utrophin transcripts. Our results show that utrophin transcripts associate preferentially with cytoskeleton-bound polysomes via actin microfilaments. Because this association is not evident in myoblasts, our findings also indicate that the localization of utrophin transcripts with cytoskeleton-bound polysomes is under developmental influences. Transfection of LacZ reporter constructs containing the utrophin 3'UTR showed that this region is critical for targeting chimeric mRNAs to cytoskeleton-bound polysomes and controlling transcript stability. Deletion studies resulted in the identification of distinct regions within the 3'UTR responsible for targeting and stabilizing utrophin mRNAs. Together, these results illustrate the contribution of posttranscriptional events in the regulation of utrophin in skeletal muscle. Accordingly, these findings provide novel targets, in addition to transcriptional events, for which pharmacological interventions may be envisaged to ultimately increase the endogenous levels of utrophin in skeletal muscle fibers from Duchenne muscular dystrophy (DMD) patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.