ArticleGenes and immunity2001
NFkappaB polymorphisms and susceptibility to type 1 diabetes.
Article in Genes and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- NFKB1 -94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies.Oncotarget · 2017Pooled it
- Spontaneous Myocarditis in Mice Predisposed to Autoimmune Disease: Including Vaccination-Induced Onset.Biomedicines · 2022Article
- Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.Frontiers in immunology · 2018Review
- The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro.Diabetologia · 2016Article
- A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo.Cell death & disease · 2015Article
- Peptide-based inhibition of IκB kinase/nuclear factor-κB pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes.Diabetologia · 2015Article
- Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IΚBα/NF-κB signaling pathway.The Journal of nutritional biochemistry · 2015Article
- Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway.The Journal of nutritional biochemistry · 2014Article
- Investigation of NF-κB1 and NF-κBIA gene polymorphism in non-small cell lung cancer.BioMed research international · 2014Article
- TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.Frontiers in immunology · 2013Article
- Anti-inflammatory therapy in type 1 diabetes.Current diabetes reports · 2012Review
- Genome-wide copy number variation (CNV) in patients with autoimmune Addison's disease.BMC medical genetics · 2011Article
- TNF receptor 2 pathway: drug target for autoimmune diseases.Nature reviews. Drug discovery · 2010Review
- NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms.Current genomics · 2008Article
- Association of NFKB1 -94ins/del ATTG promoter polymorphism with susceptibility to and phenotype of Graves' disease.Genes and immunity · 2007Article
- Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.BMC medical genetics · 2006Article
- SUMO wrestling with type 1 diabetes.Journal of molecular medicine (Berlin, Germany) · 2005Review
- Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.Genes and immunity · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear factor kappa B (NFkappaB) is an important transcription factor that is involved in the response to oxidative stress and inflammation. Recent studies suggest that it may be involved in the development of diabetic microvascular complications. A highly polymorphic (CA) dinucleotide repeat microsatellite has been identified in the regulatory region of the NFkappaB gene. The aim of this study was to investigate whether this polymorphic region was associated with susceptibility to type 1 diabetes, or its late complications. Genomic DNA was extracted from the peripheral blood of 217 patients with type 1 diabetes mellitus (T1DM) and 111 normal healthy controls. In our population 18 alleles (A1-A18) were identified. There was a highly significant decrease in the frequency of allele 146 bp (A14) in type 1 diabetes (0.03) compared with the normal controls (0.28) (chi(2) = 79.8, Pc = 0.00001). In contrast, the frequency of the allele 138 bp (A10) was significantly increased in patients with type 1 diabetes (0.17) compared with the normal controls (0.02) (chi(2) = 32.8, P < 0.00000). These results demonstrate that the NFkappaB gene may play a role in the susceptibility to type 1 diabetes: individuals with the A10 allele may be more likely to develop diabetes compared with the A14 allele.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.