ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 117 citations in OpenAlex.
- CO and NO Coordinate Developmental Neuron Migration.International journal of molecular sciences · 2025Article
- The Role of Nitric Oxide in Stem Cell Biology.Antioxidants (Basel, Switzerland) · 2022Review
- Nutrient restriction causes reversible G2 arrest inDevelopment (Cambridge, England) · 2019Article
- HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the DevelopingFrontiers in cellular neuroscience · 2016Article
- A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression.Scientific reports · 2015Article
- HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.PloS one · 2015Article
- Review article: carbon monoxide in gastrointestinal physiology and its potential in therapeutics.Alimentary pharmacology & therapeutics · 2013Review
- Neuronal-glial Interactions Define the Role of Nitric Oxide in Neural Functional Processes.Current neuropharmacology · 2012Article
- Role of nitric oxide in cerebellar development and function: focus on granule neurons.Cerebellum (London, England) · 2012Review
- In vivo time-lapse imaging of cell proliferation and differentiation in the optic tectum of Xenopus laevis tadpoles.The Journal of comparative neurology · 2012Article
- Leukaemia inhibitory factor stimulates proliferation of olfactory neuronal progenitors via inducible nitric oxide synthase.PloS one · 2012Article
- Nitric oxide-donor SNAP induces Xenopus eggs activation.PloS one · 2012Article
- Visual activity regulates neural progenitor cells in developing xenopus CNS through musashi1.Neuron · 2010Article
- Roles for gamma-aminobutyric acid in the development of the paraventricular nucleus of the hypothalamus.The Journal of comparative neurology · 2010Article
- Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions.Neurobiology of aging · 2010Article
- Regulation of radial glial motility by visual experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Pneumococcal cell wall-induced meningitis impairs adult hippocampal neurogenesis.Infection and immunity · 2007Article
- Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Nitric oxide decreases ammonium release in tadpoles of the clawed frog, Xenopus laevis, Daudin.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
- Age-related changes of NADPH-diaphorase positivity in the rat rostral migratory stream.Cellular and molecular neurobiology · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms controlling the transition of a neural precursor cell from proliferation to differentiation during brain development determine the distinct anatomical features of the brain. Nitric oxide (NO) may mediate such a transition, because it can suppress DNA synthesis and cell proliferation. We cloned the gene encoding the neuronal isoform of Xenopus NO synthase (XNOS) and found that in the developing brain of Xenopus tadpoles, a zone of XNOS-expressing cells lies adjacent to the zone of dividing neuronal precursors. Exogenous NO, supplied to the tadpole brain in vivo, decreased the number of proliferating cells and the total number of cells in the optic tectum. Conversely, inhibition of NOS activity in vivo increased the number of proliferating cells and the total number of cells in the optic tectum. NOS inhibition yielded larger brains with grossly perturbed organization. Our results indicate that NO is an essential negative regulator of neuronal precursor proliferation during vertebrate brain development.
Indexed as
Identifiers
11698593PMC6762272W1598492683What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.