Evidence map›Paper›PMID 11815510›Full record

ArticleDiabetes care2002

Health outcomes of severely obese type 2 diabetic subjects 1 year after laparoscopic adjustable gastric banding.

John B Dixon, Paul E O'Brien

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Diabetes care, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419624 (A 28-week, Multi-center Randomized, Double-blind, Placebo-controlled Study to Evaluate the Potential of Dapagliflozin Plus Exenatide in Combination With High-dose Intensive Insulin Therapy Compared to Placebo in Obese Insulin-resistant Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 69 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 4 pooled it
25.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419624 phase3terminatedstarted 2018, after this paper: background citation

A 28-week, Multi-center Randomized, Double-blind, Placebo-controlled Study to Evaluate the Potential of Dapagliflozin Plus Exenatide in Combination With High-dose Intensive Insulin Therapy Compared to Placebo in Obese Insulin-resistant Patients With Type 2 Diabetes Mellitus (Proof-of-concept Study)

Ran2018Enrolled13Registered outcomes7Posted comparisons0ConditionsDiabetes Mellitus, Type 2, ObesityArmsDapagliflozin 10mg, Exenatide 2 mg [Bydureon], Insulin, Metformin, if taken before, Placebo injection
PMID 27651331PMID 18613325PMID 22431673PMID 26213556PMID 25436106PMID 24741511PMID 24251534PMID 22608371PMID 18165348PMID 20609969PMID 22526604PMID 22517736other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 319 citations in OpenAlex.

  1. Depressive symptoms at short-, medium-, and long-term follow-up after bariatric surgical procedures: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
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  3. Bariatric surgery: an IDF statement for obese Type 2 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2011 · on this map
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  16. Obesity management for the treatment of type 2 diabetes: emerging evidence and therapeutic approaches.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024
    Review
  17. Review
  18. Remission of Type 2 Diabetes Mellitus after Bariatric Surgery: Fact or Fiction?International journal of environmental research and public health · 2019
    Review
  19. Article
  20. A prospective 4-year study of insulin resistance and adipokines in morbidly obese diabetic and non-diabetic patients after gastric banding.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2017
    Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John B DixonDepartment of Surgery, Monash University, Alfred Hospital, Melbourne 3181, Victoria, Australia. john.dixon@med.monash.edu.au
Paul E O'Brien
Monash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo prospectively examine the effect of weight loss 1 year after laparoscopic adjustable gastric band surgery on a broad range of health outcomes in 50 diabetic subjects. RESEARCH DESIGN AND

methodsA total of 50 (17 men, 33 women) of 51 patients with type 2 diabetes, from a total of 500 consecutive patients, were studied preoperatively and again 1 year after surgery.

resultsPreoperative weight and BMI (means +/- SD) were 137 +/- 30 kg and 48.2 +/- 8 kg/m(2), respectively; at 1 year, weight and BMI were 110 +/- 24 kg and 38.7 +/- 6 kg/m(2), respectively. There was significant improvement in all measures of glucose metabolism. Remission of diabetes occurred in 32 patients (64%), and major improvement of glucose control occurred in 13 patients (26%); glucose metabolism was unchanged in 5 patients (10%). HbA(1c) was 7.8 +/- 3.2% preoperatively and 6.2 +/- 2.7% at 1 year (P < 0.001). Remission of diabetes was predicted by greater weight loss and a shorter history of diabetes (pseudo r(2) = 0.44, P < 0.001). Improvement in diabetes was related to increased insulin sensitivity and beta-cell function. Weight loss was associated with significant improvements in fasting triglyceride level, HDL cholesterol level, hypertension, sleep, depression, appearance evaluation, and health-related quality of life. Early complications occurred in 6% of patients (wound infections in 4%, respiratory support in 2%), and late complications occurred in 30% of patients (gastric prolapse in 20%, band erosion in 6%, and tubing leaks in 4%). All late complications were successfully revised surgically.

conclusionsModern laparoscopic weight-loss surgery is effective in managing the broad range of health problems experienced by severely obese individuals with type 2 diabetes. Surgery should be considered as an early intervention.

Indexed as

GastroplastyAlanine TransaminaseAspartate AminotransferasesBlood GlucoseCholesterolDepressionDiabetes Mellitus, Type 2Femalegamma-GlutamyltransferaseHumansHyperlipidemiasHypertensionInsulinIslets of LangerhansLaparoscopyMaleAlanine TransaminaseAspartate AminotransferasesBlood GlucoseCholesterolgamma-GlutamyltransferaseInsulin

Identifiers

PMID11815510
OpenAlexW2114392594

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.