ReviewCurrent psychiatry reports2002
Family, twin, and adoption studies of bipolar disease.
Review in Current psychiatry reports, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis.PloS one · 2022Pooled it
- African-American representation in family and twin studies of mood and anxiety disorders: A systematic review.Journal of affective disorders · 2016Pooled it
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- Bipolar disorder in an evolutionary framework: rethinking adaptation, vulnerability, and stigma.Frontiers in psychiatry · 2026Article
- Neural correlates of reward processing distinguish healthy youth at familial risk for bipolar disorder from youth at familial risk for major depressive disorder.Translational psychiatry · 2022Article
- An Extended Swedish National Adoption Study of Bipolar Disorder Illness and Cross-Generational Familial Association With Schizophrenia and Major Depression.JAMA psychiatry · 2020Article
- Decreased Functional Connectivity in Insular Subregions in Depressive Episodes of Bipolar Disorder and Major Depressive Disorder.Frontiers in neuroscience · 2018Article
- Positive Traits in the Bipolar Spectrum: The Space between Madness and Genius.Molecular neuropsychiatry · 2017Review
- Childhood adverse life events and parental psychopathology as risk factors for bipolar disorder.Translational psychiatry · 2016Article
- A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.Journal of affective disorders · 2016Article
- Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population.Neuroscience bulletin · 2014Article
- Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.Genome medicine · 2014Review
- Heritability and linkage analysis of personality in bipolar disorder.Journal of affective disorders · 2013Article
- Bipolar disorder in children and adolescents.Child and adolescent mental health · 2013Article
- Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder.PloS one · 2013Article
- Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?Expert review of neurotherapeutics · 2012Review
- Further evidence for linkage of bipolar disorder to chromosomes 6 and 17 in a new independent pedigree series.Bipolar disorders · 2012Article
- Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Pharmacogenomics of mood stabilizers in the treatment of bipolar disorder.Human genomics and proteomics : HGP · 2010Article
- Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bipolar disease features states of severe depression that usually fluctuate with at least one episode of intense elation or mania. It is a disorder that has been thought for some time to have a heritable component. The lifetime prevalence of bipolar disease in the general population is approximately 1%. In contrast, family studies have shown the approximate lifetime risk of a first-degree relative of a bipolar proband to be 5% to 10%. Moreover, studies of monozygotic twins show that their risk of contracting the disease is as much as 75 times greater than that for the general population. In addition, adoption studies have demonstrated that biological relatives of bipolar patients are substantially more likely to have the disorder than are adoptive relatives.
Indexed as
Identifiers
11914174What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.