ArticleNucleic acids research2002
A putative RNA editing from U to C in a mouse mitochondrial transcript.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- CD43 expressed in Sertoli, Leydig and germ cells inhibits testicular function and represents a potential target to treat male infertility or effect male contraception.Reproductive biology and endocrinology : RB&E · 2025Article
- Non-Coding RNAs of Mitochondrial Origin: Roles in Cell Division and Implications in Cancer.International journal of molecular sciences · 2024Review
- ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts.Frontiers in cell and developmental biology · 2022Article
- Mitochondrial Epigenetics: Non-Coding RNAs as a Novel Layer of Complexity.International journal of molecular sciences · 2020Review
- A rice dual-localized pentatricopeptide repeat protein is involved in organellar RNA editing together with OsMORFs.Journal of experimental botany · 2018Article
- Mitochondrial Epigenetics and Environmental Exposure.Current environmental health reports · 2016Review
- RES-Scanner: a software package for genome-wide identification of RNA-editing sites.GigaScience · 2016Article
- Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.Oncogene · 2016Article
- Parallel Evolution and Lineage-Specific Expansion of RNA Editing in Ctenophores.Integrative and comparative biology · 2015Review
- Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes.The Journal of biological chemistry · 2012Article
- Accurate identification of A-to-I RNA editing in human by transcriptome sequencing.Genome research · 2012Article
- Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Expression of a novel non-coding mitochondrial RNA in human proliferating cells.Nucleic acids research · 2007Article
- RNA editing generates tissue-specific sodium channels with distinct gating properties.The Journal of biological chemistry · 2004Article
- Genome-wide gene expression patterns in dikaryon of the basidiomycete fungus Pleurotus ostreatus.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, we isolated and characterized a new mouse mitochondrial RNA molecule containing the mitochondrial 16S RNA plus 121 nt joined to the 5' end of the RNA. This fragment arises from the L strand of the same gene and we have named this transcript chimeric RNA. At position 121 of the RNA there is a C, which, according to the sequence of the mitochondrial 16S RNA gene, should be a U. We hypothesized that this RNA is synthesized having a U at position 121, which is later substituted to a C by a putative editing reaction. Based on the presence of sites for the restriction endonucleases RsaI and Fnu4HI around position 121, both forms of the RNA were detected in mouse tissues. To confirm the presence of the non-edited and putative edited RNA, a fragment containing the first 154 nt of the RNA was amplified by RT-PCR and cloned. The substitution of U for C was demonstrated by sequencing these clones. In vitro transcription experiments demonstrated that the substitution of U for C is not due to artifact of amplification or cloning. Moreover, in mitochondria from testis only the non-edited form was found. This, together with other experimental evidence, demonstrated that the base substitution was not due to polymorphism of the mitochondrial 16S RNA gene. This is the first demonstration of a substitution reaction from U to C in a mammalian mitochondrial transcript.
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