Evidence map›Paper›PMID 12176951›Full record

Trial reportCirculation2002

Multiple atherosclerotic plaque rupture in acute coronary syndrome: a three-vessel intravascular ultrasound study.

G Rioufol, G Finet, I Ginon, X André-Fouët, R Rossi, E Vialle, E Desjoyaux, G Convert, J F Huret, A Tabib

Retracted Registry-linked trialOpen access · bronzeAbstract readClinical TrialRetracted Publication
PubMed Publisher
In one paragraph

Trial report in Circulation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT01200056 (A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound), which is not on this map. Cited by 122 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 1 pooled it
53.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01200056 phase4completedstarted 2007, after this paper: background citation

A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound

Ran2007Enrolled40Registered outcomes2Posted comparisons0ConditionsCoronary Disease, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Ultrasonography, InterventionalArmsAtorvastatin 10mg versus 40mg.
PMID 15519006PMID 15249516PMID 15755765PMID 15007110PMID 12114036PMID 12390948PMID 10687795PMID 11277825PMID 11300468PMID 11368702PMID 11468198PMID 11584167other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 1 synthesis or guideline pooled it, 690 citations in OpenAlex.

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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

G RioufolDepartment of Hemodynamics, Cardiovascular Hospital and Claude Bernard University, Lyon, France. gilles.rioufol@univ-lyon1.fr
G Finet
I Ginon
X André-Fouët
R Rossi
E Vialle
E Desjoyaux
G Convert
J F Huret
A Tabib
Centre Hospitalier Annecy Genevois · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo test the hypothesis of general atherosclerotic plaque destabilization during acute coronary syndrome (ACS), the present study sought to analyze the 3 coronary arteries by systematic intravascular ultrasound scan (IVUS). METHODS AND

resultsSeventy-two arteries were explored in 24 patients referred for percutaneous coronary intervention after a first ACS with troponin I elevation. Fifty plaque ruptures (mean, 2.08 per patient; range, 0 to 6) were diagnosed by the association of a ruptured capsule with intraplaque cavity. Plaque rupture on the culprit lesion was found in 9 patients (37.5%). At least 1 plaque rupture was found somewhere other than on the culprit lesion in 19 patients (79%). These lesions were in a different artery than the culprit artery in 70.8% and were in both other arteries in 12.5% of these 24 patients. Complete IVUS examination of all 3 coronary axes in patients who had experienced a first ACS revealed that multiple atherosclerotic plaque ruptures were detected by IVUS; these multiple ruptures were present simultaneously with the culprit lesion; they were frequent and located (in three quarters of cases) on the 3 principal coronary trunks; and the multiple plaque ruptures in locations other than on the culprit lesion were less severe, nonstenosing, and less calcified.

conclusionAlthough one single lesion is clinically active at the time of ACS, the syndrome seems nevertheless associated with overall coronary instability.

Indexed as

Ultrasonography, InterventionalAcute DiseaseAdrenergic beta-AntagonistsAngioplasty, Balloon, CoronaryCalcinosisCoronary AngiographyCoronary Artery DiseaseDisease ProgressionFemaleFollow-Up StudiesHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexAdrenergic beta-AntagonistsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa Complex

Identifiers

PMID12176951
OpenAlexW2001044397

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.