ArticleThe New England journal of medicine2002
Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes.
Article in The New England journal of medicine, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 216 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Dapagliflozin on Nighttime Blood Pressure in Type 2 Diabetes
Nocturnal Hypertension and Prevention of Microalbuminuria in Type 1 Diabetes
Randomized Trial to Explore the Effect of Chronotherapy Versus Conventional BP Control to Correct Abnormal Circadian BP Pattern and Improve Allograft Function in Kidney Transplant Recipients
Who cites it
216 citing papers in PubMed, 6 syntheses or guidelines pooled it, 723 citations in OpenAlex.
- Guideline
- Home Blood Pressure Monitoring in Children and Adolescents: Systematic Review of Evidence on Clinical Utility.Current hypertension reports · 2019Pooled it
- ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents.Pediatric diabetes · 2018Guideline
- Updated Guideline May Improve the Recognition and Diagnosis of Hypertension in Children and Adolescents; Review of the 2017 AAP Blood Pressure Clinical Practice Guideline.Current hypertension reports · 2017Pooled it
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 2 - Diagnosis and ClassificationArquivos brasileiros de cardiologia · 2016Guideline
- Update: ambulatory blood pressure monitoring in children and adolescents: a scientific statement from the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2014Guideline
- Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D.Scientific reports · 2020Trial
- Effect of Intensive Versus Standard Clinic-Based Hypertension Management on Ambulatory Blood Pressure: Results From the SPRINT (Systolic Blood Pressure Intervention Trial) Ambulatory Blood Pressure Study.Hypertension (Dallas, Tex. : 1979) · 2017Trial
- A trial of 2 strategies to reduce nocturnal blood pressure in blacks with chronic kidney disease.Hypertension (Dallas, Tex. : 1979) · 2013Trial
- Resting heart rate and the risk of microvascular complications in patients with type 2 diabetes mellitus.Journal of the American Heart Association · 2012Trial
- Short-term reproducibility of ambulatory blood pressure monitoring in autosomal dominant polycystic kidney disease.Blood pressure monitoring · 2011Trial
- Evaluation of dosing time-related anti-hypertensive efficacy of valsartan in patients with type 2 diabetes.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2011Trial
- Trial
- Telemedicine home blood pressure measurements and progression of albuminuria in elderly people with diabetes.Hypertension (Dallas, Tex. : 1979) · 2008Trial
- Loss of Nocturnal Dipping in Type 2 Diabetes Mellitus According to Diabetic Kidney Disease: The Role of Vitamin D Levels.Nutrients · 2026Article
- Increased 24-h blood pressure and arterial stiffness in young adults with childhood-onset type 1 diabetes: the Norwegian Atherosclerosis and Childhood Diabetes study.Journal of hypertension · 2026Article
- Abnormal circadian pattern of urinary sodium excretion and chronic kidney disease progression.BMC nephrology · 2026Article
- Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy.FASEB bioAdvances · 2026Article
- Optimal nighttime blood pressure monitoring schedule using home monitors in children and adolescents: association with ambulatory blood pressure and preclinical target-organ damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The potential of nighttime urine samples for epidemiologic research on sodium intake: Evidence from a population-based cohort study in Switzerland.The American journal of clinical nutrition · 2025Article
156 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with type 1 diabetes mellitus and microalbuminuria often have elevated blood pressure while they are asleep, but it is not known whether the elevation develops concomitantly with microalbuminuria or precedes it.
methodsWe monitored 75 adolescents and young adults who had had type 1 diabetes with normal urinary albumin excretion and blood pressure for more than five years. Ambulatory blood-pressure monitoring was used to assess blood pressure at the initial evaluation and about two years later, at which time all subjects had normal urinary albumin excretion. Subsequently, subjects were monitored for the development of microalbuminuria.
resultsMicroalbuminuria developed in 14 subjects, whereas the other 61 continued to have normal urinary albumin excretion. The mean (+/-SD) systolic pressure during sleep increased significantly in the subjects who ultimately had microalbuminuria (from 109.9+/-11.3 to 114.9+/-11.7 mm Hg, P=0.01) but not in the subjects with normal albumin excretion (from 106.0+/-8.8 to 106.4+/-14.8 mm Hg). The risk of progression to microalbuminuria was examined in relation to the ratio of systolic pressure during sleep to systolic pressure in the daytime. A ratio of 0.9 or lower, used to define a normal fall in nocturnal pressure, had a negative predictive value of 91 percent for the development of microalbuminuria. Moreover, the risk of microalbuminuria was 70 percent lower (95 percent confidence interval, 44 to 110 percent) in subjects with a ratio of 0.9 or less than in those with a ratio higher than 0.9 (P=0.01).
conclusionsIn persons with type 1 diabetes, an increase in systolic blood pressure during sleep precedes the development of microalbuminuria. In those whose blood pressure during sleep decreases normally, the progression from normal albumin excretion to microalbuminuria appears to be less likely.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.