ArticleJournal of virology2002
Evolutionary dynamics of viral attenuation.
Article in Journal of virology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- Establishment of a highly sensitive porcine alveolar macrophage cell line for African swine fever virus.In vitro cellular & developmental biology. Animal · 2025Article
- An Overview of the Dichotomous Role of Microbiota in Cancer Progression and Management.Current cancer drug targets · 2025Review
- Will COVID-19 become mild, like a cold?Epidemiology and infection · 2024Review
- Attenuation and molecular characterization of fowl adenovirus 8b propagated in a bioreactor and its immunogenicity, efficacy, and virus shedding in broiler chickens.Veterinary world · 2024Article
- Reduced social function in experimentally evolvedProceedings. Biological sciences · 2023Article
- Seroprevalence of Zika in Brazil stratified by age and geographic distribution.Epidemiology and infection · 2023Article
- Updated analysis to reject the laboratory-engineering hypothesis of SARS-CoV-2.Environmental research · 2023Article
- SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.Nature communications · 2022Article
- Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives.Frontiers in molecular biosciences · 2021Review
- COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response.Vaccines · 2020Review
- Influence of temperature on the antigenic changes of virus-like particles.Clinical and experimental vaccine research · 2020Article
- An overview of COVID-19.Journal of Zhejiang University. Science. B · 2020Review
- Microorganisms in the Treatment of Cancer: Advantages and Limitations.Journal of immunology research · 2018Review
- Evolutionary dynamics of viral escape under antibodies stress: A biophysical model.Protein science : a publication of the Protein Society · 2016Article
- Plague Vaccines: Status and Future.Advances in experimental medicine and biology · 2016Review
- Evolutionary reversion of live viral vaccines: Can genetic engineering subdue it?Virus evolution · 2015Article
- Developing live vaccines against plague.Journal of infection in developing countries · 2011Review
- Canine parvovirus: current perspective.Indian journal of virology : an official organ of Indian Virological Society · 2010Article
- Within-host genetic diversity of endemic and emerging parvoviruses of dogs and cats.Journal of virology · 2008Article
- Comparative analysis reveals frequent recombination in the parvoviruses.The Journal of general virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The genetic trajectory leading to viral attenuation was studied in a canine parvovirus (CPV) strain grown on dog kidney cells for 115 transfers. Consensus sequences of viral populations at passages 0, 3, 30, 50, 80, and 115 were obtained from PCR products covering 86% of the genome; clones from each of the 80th and 115th passages were also sequenced, covering 69% of the genome. Sixteen changes were fixed in the 115th-passage virus sample. Levels of polymorphism were strikingly different over time, in part because of a plaque-cloning step at passage 112 that reduced variation: passage 80 had 19 variants common among the clones, but passage 115 had only a single common variant. Several mutations increased in the culture at the same time, with most reaching fixation only after the 80th passage. The pattern of evolution was consistent with recombination and not with separate selective sweeps of individual mutations. Thirteen of the changes observed were identical to or at the same positions as changes observed in other isolates of CPV or feline panleukopenia virus.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.