ArticleThe Biochemical journal2003
Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 93 citations in OpenAlex.
- Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer's disease.Cell death & disease · 2025Review
- LIM Kinases, LIMK1 and LIMK2, Are Crucial Node Actors of the Cell Fate: Molecular to Pathological Features.Cells · 2023Review
- 14-3-3 Proteins in Glutamatergic Synapses.Neural plasticity · 2018Review
- Participation of 14-3-3ε and 14-3-3ζ proteins in the phagocytosis, component of cellular immune response, in Aedes mosquito cell lines.Parasites & vectors · 2017Article
- 14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis.Frontiers in molecular neuroscience · 2017Review
- 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Redox regulation of 14-3-3ζ controls monocyte migration.Arteriosclerosis, thrombosis, and vascular biology · 2014Article
- Identification of obscure yet conserved actin-associated proteins in Giardia lamblia.Eukaryotic cell · 2014Article
- Argonaute2 regulates the pancreatic β-cell secretome.Molecular & cellular proteomics : MCP · 2013Article
- Article
- Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.Nature cell biology · 2012Article
- 14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity.Developmental neurobiology · 2012Article
- Proteomic analysis of 14-3-3 zeta binding proteins in the mouse hippocampus.International journal of physiology, pathophysiology and pharmacology · 2012Article
- Cofilin and slingshot localization in the epithelium of uterine endometrium changes during the menstrual cycle and in endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity.The Journal of biological chemistry · 2011Article
- A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.Molecular & cellular proteomics : MCP · 2011Article
- Article
- Cancer secretomics reveal pathophysiological pathways in cancer molecular oncology.Molecular oncology · 2010Review
- Analysis of newly established EST databases reveals similarities between heart regeneration in newt and fish.BMC genomics · 2010Article
- The small heat shock protein, HSPB6, in muscle function and disease.Cell stress & chaperones · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins of the 14-3-3 family have been implicated in various physiological processes, and are thought to function as adaptors in various signal transduction pathways. In addition, 14-3-3 proteins may contribute to the reorganization of the actin cytoskeleton by interacting with as yet unidentified actin-binding proteins. Here we show that the 14-3-3 zeta isoform interacts with both the actin-depolymerizing factor cofilin and its regulatory kinase, LIM (Lin-11/Isl-1/Mec-3)-domain-containing protein kinase 1 (LIMK1). In both yeast two-hybrid assays and glutathione S-transferase pull-down experiments, these proteins bound efficiently to 14-3-3 zeta. Deletion analysis revealed consensus 14-3-3 binding sites on both cofilin and LIMK1. Furthermore, the C-terminal region of 14-3-3 zeta inhibited the binding of cofilin to actin in co-sedimentation experiments. Upon co-transfection into COS-7 cells, 14-3-3 zeta-specific immunoreactivity was redistributed into characteristic LIMK1-induced actin aggregations. Our data are consistent with 14-3-3-protein-induced changes to the actin cytoskeleton resulting from interactions with cofilin and/or LIMK1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.