ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
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- Ect2, an ortholog of Drosophila Pebble, regulates formation of growth cones in primary cortical neurons.Neurochemistry international · 2012Article
- Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein.The Journal of biological chemistry · 2012Article
- Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation.The Journal of biological chemistry · 2011Article
- Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.The Journal of biological chemistry · 2010Article
- Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function.Journal of biomedical science · 2010Article
- Functional whole-genome analysis identifies Polo-like kinase 2 and poliovirus receptor as essential for neuronal differentiation upstream of the negative regulator alphaB-crystallin.The Journal of biological chemistry · 2009Article
- Impaired regulation of pH homeostasis by oxidative stress in rat brain capillary endothelial cells.Cellular and molecular neurobiology · 2005Article
- Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection.Molecular neurobiology · 2004Review
- BMP enhances transcriptional responses to NGF during PC12 cell differentiation.Neurochemical researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used serial analysis of gene expression to identify new NGF-responsive immediate early genes (IEGs) with potential roles in neuronal differentiation. Among those identified was MafK, a small Maf family basic region and leucine zipper transcriptional repressor and coactivator expressed in immature neurons. NGF treatment elevates the levels of both MafK transcripts and protein. In contrast, there is no effect on expression of the closely related MafG. Unlike many other NGF-responsive IEGs, MafK regulation shows selectivity and is unresponsive to epidermal growth factor, depolarization, or cAMP derivatives. Inhibitor studies indicate that NGF-promoted MafK regulation is mediated by an atypical isoform of PKC but not by mitogen-activated kinase kinase, phospholipase Cgamma, or phosphoinositide 3'-kinase. Interference with MafK expression or activity by small interfering RNA and dominant negative strategies, respectively, suppresses NGF-promoted outgrowth and maintenance of neurites by PC12 cells and neurite outgrowth by immature telencephalic neurons. Our findings support a role for MafK as a novel regulator of neuronal differentiation.
Indexed as
Identifiers
12388604PMC6757672W1935140087What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.