Evidence map›Paper›PMID 12390948›Full record

ArticleCirculation2002

Coronary plaque classification with intravascular ultrasound radiofrequency data analysis.

Anuja Nair, Barry D Kuban, E Murat Tuzcu, Paul Schoenhagen, Steven E Nissen, D Geoffrey Vince

2 registry-linked trialsOpen access · bronzeAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Circulation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 269 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
269citing papers in PubMed, 2 pooled it
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01058915 nacompletedstarted 2007, after this paper: background citation

Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Plaque Composition Assessed by Virtual Histology in Patients With ST-Segment Elevation Acute Myocardial Infarction (VIRHISTAMI)

Ran2007Enrolled87Registered outcomes2Posted comparisons0ConditionsAcute Coronary SyndromeArmsRosuvastatin 40mg, Rosuvastatin 5mg
PMID 15238460other papers from this trial
Open the trial in the graph
NCT01200056 phase4completedstarted 2007, after this paper: background citation

A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular Ultrasound

Ran2007Enrolled40Registered outcomes2Posted comparisons0ConditionsCoronary Disease, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Ultrasonography, InterventionalArmsAtorvastatin 10mg versus 40mg.
PMID 15519006PMID 15249516PMID 15755765PMID 15007110PMID 12114036PMID 7759694PMID 9659192PMID 9202362PMID 10687795PMID 11277825PMID 11300468PMID 11368702other papers from this trial
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3 · Its place in the literature

Who cites it

269 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,124 citations in OpenAlex.

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209 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anuja NairDepartment of Biomedical Engineering, The Cleveland Clinic Foundation, OH 44195, USA.
Barry D Kuban
E Murat Tuzcu
Paul Schoenhagen
Steven E Nissen
D Geoffrey Vince
Williams & Associates · US

Funding

HIGH FREQUENCY NONLINEAR ACOUSTIC INTRAVASCULAR IMAGINGR01HL069094 · VOLCANO CORPORATION · 2002 to 2005
$2.4M
IDENTIFICATION OF VULNERABLE PLAQUESR01HL064686 · VOLCANO CORPORATION · 2002 to 2005
$1.2M
NHLBI NIH HHS R01HL069094NHLBI NIH HHS R01HL64686
6 · The paper itself

Abstract

backgroundAtherosclerotic plaque stability is related to histological composition. However, current diagnostic tools do not allow adequate in vivo identification and characterization of plaques. Spectral analysis of backscattered intravascular ultrasound (IVUS) data has potential for real-time in vivo plaque classification. METHODS AND

resultsEighty-eight plaques from 51 left anterior descending coronary arteries were imaged ex vivo at physiological pressure with the use of 30-MHz IVUS transducers. After IVUS imaging, the arteries were pressure-fixed and corresponding histology was collected in matched images. Regions of interest, selected from histology, were 101 fibrous, 56 fibrolipidic, 50 calcified, and 70 calcified-necrotic regions. Classification schemes for model building were computed for autoregressive and classic Fourier spectra by using 75% of the data. The remaining data were used for validation. Autoregressive classification schemes performed better than those from classic Fourier spectra with accuracies of 90.4% for fibrous, 92.8% for fibrolipidic, 90.9% for calcified, and 89.5% for calcified-necrotic regions in the training data set and 79.7%, 81.2%, 92.8%, and 85.5% in the test data, respectively. Tissue maps were reconstructed with the use of accurate predictions of plaque composition from the autoregressive classification scheme.

conclusionsCoronary plaque composition can be predicted through the use of IVUS radiofrequency data analysis. Autoregressive classification schemes performed better than classic Fourier methods. These techniques allow real-time analysis of IVUS data, enabling in vivo plaque characterization.

Indexed as

AlgorithmsAutomationCoronary Artery DiseaseCoronary VesselsFemaleFourier AnalysisHumansMaleMiddle AgedUltrasonography

Identifiers

PMID12390948
OpenAlexW2109286340

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.