ArticleMolecular and cellular biology2002
Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract.
Article in Molecular and cellular biology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- NGS Analysis Confirms CommonInternational journal of molecular sciences · 2021Article
- Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.Hepatology (Baltimore, Md.) · 2015Article
- Perturbation of NCOA6 leads to dilated cardiomyopathy.Cell reports · 2014Article
- Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms.International journal of biological sciences · 2011Article
- Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.Molecular biology of the cell · 2010Article
- Retinoic acid signaling in mammalian eye development.Experimental eye research · 2009Review
- Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages.Molecular endocrinology (Baltimore, Md.) · 2009Article
- A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Roles of histone H3-lysine 4 methyltransferase complexes in NR-mediated gene transcription.Progress in molecular biology and translational science · 2009Review
- Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development.Nuclear receptor signaling · 2008Review
- Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice.Molecular and cellular biology · 2007Article
- Genetic and epigenetic mechanisms of gene regulation during lens development.Progress in retinal and eye research · 2007Review
- Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2.Molecular and cellular biology · 2006Article
- Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.The International journal of developmental biology · 2004Review
- Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.Molecular and cellular biology · 2003Article
- Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ASC-2, a recently isolated transcriptional coactivator molecule, stimulates transactivation by multiple transcription factors, including nuclear receptors. We generated a potent dominant negative fragment of ASC-2, encompassing the N-terminal LXXLL motif that binds a broad range of nuclear receptors. This fragment, termed DN1, specifically inhibited endogenous ASC-2 from binding these receptors in vivo, whereas DN1/m, in which the LXXLL motif was mutated to LXXAA to abolish the receptor interactions, was inert. Interestingly, DN1 transgenic mice but not DN1/m transgenic mice exhibited severe microphthalmia and posterior lenticonus with cataract as well as a variety of pathophysiological phenotypes in many other organs. Our results provide a novel insight into the molecular and histopathological mechanism of posterior lenticonus with cataract and attest to the importance of ASC-2 as a pivotal transcriptional coactivator of nuclear receptors in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.