Evidence map›Paper›PMID 12460879›Full record

ArticleCirculation2002

Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction.

Ellen O Weinberg, Masahisa Shimpo, Gilles W De Keulenaer, Catherine MacGillivray, Shin-ichi Tominaga, Scott D Solomon, Jean-Lucien Rouleau, Richard T Lee

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05335629 (Evaluation of the Effect of Dapagliflozin on Cardiac Remodeling in Post Myocardial Infarction Patients), which is not on this map. Cited by 277 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
277citing papers in PubMed, 5 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05335629 nacompletedstarted 2022, after this paper: background citation

Evaluation of the Effect of Dapagliflozin on Cardiac Remodeling in Post Myocardial Infarction Patients

Ran2022Enrolled54Registered outcomes2Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Myocardial Infarction, Myocardial Remodeling, VentricularArmsDapagliflozin 10mg Tab
PMID 30710997PMID 32626540PMID 10491084PMID 15110792PMID 15226248PMID 16286016PMID 17492053PMID 17692745PMID 21943940PMID 2532153PMID 25464491PMID 25748771other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

277 citing papers in PubMed, 5 syntheses or guidelines pooled it, 635 citations in OpenAlex.

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  10. Preoperative serum ST2 level predicts acute kidney injury after adult cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2018
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217 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ellen O WeinbergCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Mass 02139, USA.
Masahisa Shimpo
Gilles W De Keulenaer
Catherine MacGillivray
Shin-ichi Tominaga
Scott D Solomon
Jean-Lucien Rouleau
Richard T Lee
Jichi Medical University · JP

Funding

THE NO PATHWAY AND REGULATION OF MYOCARDIAL FUNCTIONP50HL052320 · BRIGHAM AND WOMEN'S HOSPITAL · 1995 to 2004
$7.8M
INNATE IMMUNITY AND MYOCARDIAL INJURYR01HL063927 · BRIGHAM AND WOMEN'S HOSPITAL · 2000 to 2003
$1.7M
Role of the T1/ST2 receptor in myocardial ischemia/repe*R01HL069484 · BRIGHAM AND WOMEN'S HOSPITAL · 2001 to 2004
$1.7M
NHLBI NIH HHS HL052320NHLBI NIH HHS HL63927NHLBI NIH HHS HL69484NHLBI NIH HHS P50 HL052320NHLBI NIH HHS R01 HL063927NHLBI NIH HHS R01 HL069484NHLBI NIH HHS R01 HL069484-01
6 · The paper itself

Abstract

backgroundWe identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes and hypothesized that ST2 participates in the acute myocardial response to stress and injury. METHODS AND

resultsST2 mRNA was induced in cardiac myocytes by mechanical strain (4.7+/-0.9-fold) and interleukin-1beta (2.0+/-0.2-fold). Promoter analysis revealed that the proximal and not the distal promoter of ST2 is responsible for transcriptional activation in cardiac myocytes by strain and interleukin-1beta. In mice subjected to coronary artery ligation, serum ST2 was transiently increased compared with unoperated controls (20.8+/-4.4 versus 0.8+/-0.8 ng/mL, P<0.05). Soluble ST2 levels were increased in the serum of human patients (N=69) 1 day after myocardial infarction and correlated positively with creatine kinase (r=0.41, P<0.001) and negatively with ejection fraction (P=0.02).

conclusionsThese data identify ST2 release in response to myocardial infarction and suggest a role for this innate immune receptor in myocardial injury.

Indexed as

Angiotensin IIAngiotensin Receptor AntagonistsAnimalsAnimals, NewbornBiomarkersCells, CulturedDisease Models, AnimalGene Expression RegulationHumansImidazolesInterleukin-1Interleukin-1 Receptor-Like 1 ProteinInterleukin-4LipopolysaccharidesMembrane ProteinsMiceAngiotensin IIAngiotensin Receptor AntagonistsBiomarkersCP 191166IL1RL1 protein, humanIl1rl1 protein, mouseImidazolesInterleukin-1Interleukin-1 Receptor-Like 1 ProteinInterleukin-4LipopolysaccharidesMembrane ProteinsPhorbol EstersPyridinesReceptor, Angiotensin, Type 1Receptors, Cell SurfaceReceptors, InterleukinReceptors, Interleukin-1RNA, MessengerST2 protein, ratNon-programmatic

Identifiers

PMID12460879
PMCPMC1460012
OpenAlexW2084671075

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.