ArticleThe Journal of physiology2003
Prenatal dexamethasone leads to both endothelial dysfunction and vasodilatory compensation in sheep.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Prenatal glucocorticoids exposure and adverse cardiovascular effects in offspring.Frontiers in endocrinology · 2024Review
- Programming of Vascular Dysfunction by Maternal Stress: Immune System Implications.Frontiers in physiology · 2022Review
- A Scoping Review of Life-Course Psychosocial Stress and Kidney Function.Children (Basel, Switzerland) · 2021Article
- Poor perinatal growth impairs baboon aortic windkessel function.Journal of developmental origins of health and disease · 2018Article
- The effects of dexamethasone on post-asphyxial cerebral oxygenation in the preterm fetal sheep.The Journal of physiology · 2014Article
- The association of maternal prenatal psychosocial stress with vascular function in the child at age 10-11 years: findings from the Avon longitudinal study of parents and children.European journal of preventive cardiology · 2014Article
- Antenatal betamethasone increases vascular reactivity to endothelin-1 by upregulation of CD38/cADPR signaling.Journal of developmental origins of health and disease · 2014Article
- Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity.Current vascular pharmacology · 2013Review
- Antenatal betamethasone has a sex-dependent effect on the in vivo response to endothelin in adult sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Prenatal exposure to dexamethasone in the mouse alters cardiac growth patterns and increases pulse pressure in aged male offspring.PloS one · 2013Article
- The association between prenatal psychosocial stress and blood pressure in the child at age 5-7 years.PloS one · 2012Article
- Antenatal betamethasone alters vascular reactivity in adult female ovine cerebral arteries.Pediatric research · 2010Article
- Antioxidant treatment alters peripheral vascular dysfunction induced by postnatal glucocorticoid therapy in rats.PloS one · 2010Article
- Long-term effects of prenatal hypoxia on endothelium-dependent relaxation responses in pulmonary arteries of adult sheep.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Role of fetal programming in the development of hypertension.Future cardiology · 2008Article
- Antenatal and postnatal risk factors for neonatal hypertension and infant follow-up.Pediatric nephrology (Berlin, Germany) · 2007Article
- Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood.The Journal of physiology · 2007Article
- Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2005Article
- Fetal cardiovascular, metabolic and endocrine responses to acute hypoxaemia during and following maternal treatment with dexamethasone in sheep.The Journal of physiology · 2005Article
- Maternal nutrient restriction and the fetal left ventricle: decreased angiotensin receptor expression.Reproductive biology and endocrinology : RB&E · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We investigated long-term cardiovascular effects in the offspring of sheep exposed to prenatal dexamethasone (DM). We assessed in vitro vascular responsiveness and evaluated endothelial nitric oxide synthase (eNOS) message and protein levels in femoral muscle removed from 5-month-old sheep. Dexamethasone was administered i.m. to pregnant ewes as 3 weekly courses (4 x 2 mg at 12 h intervals), starting on day 103 of gestation (term approximately 149 days). Ewes were allowed to lamb. At 5 months of age a carotid catheter was placed for blood pressure measurement and hamstring muscle was removed from the lambs under general anaesthesia. We demonstrate that following prenatal DM exposure in the 5-month-old offspring: (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. We speculate that decreased agonist-induced NO release is not due to alteration in gene expression, but is more likely to be a post-transcriptional event. In summary, the lack of a difference in resting mean arterial pressure (MAP) between DM and control lambs indicates that the compensation we have previously demonstrated in the fetus following glucocorticoid exposure persists to 5 months postnatal age. Compensation is likely due to non-NO-dependent mechanisms, since no evidence was found of upregulated NOS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.