ReviewPediatric research2003
Genetics and the pathophysiology of obesity.
Review in Pediatric research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00941382 (Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients
Who cites it
19 citing papers in PubMed, 103 citations in OpenAlex.
- How Adipocytes Orchestrate Inflammation Within Adipose Tissue?Biomolecules · 2025Review
- Article
- Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue.International journal of molecular sciences · 2023Article
- An exposome-wide association study on body mass index in adolescents using the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2013-2014 data.Scientific reports · 2022Article
- Sodium intake assessed by 24-h urine excretion and its relationship with anthropometric measurements in Malaysian adults.Journal of health, population, and nutrition · 2021Article
- The Influence of Socioeconomic Status on Snacking and Weight among Adolescents: A Scoping Review.Nutrients · 2020Article
- Anti-Obesity Effects ofMicroorganisms · 2019Article
- Associations of Obesity and Dyslipidemia with Intake of Sodium, Fat, and Sugar among Koreans: a Qualitative Systematic Review.Clinical nutrition research · 2016Article
- Genetics of Obesity.Indian journal of clinical biochemistry : IJCB · 2016Review
- Article
- Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective.Molecular genetics and genomics : MGG · 2015Review
- Determinants of overweight and obesity among Bangladeshi diabetic women of reproductive age.BMC research notes · 2014Article
- Health-related knowledge and preferences in low socio-economic kindergarteners.The international journal of behavioral nutrition and physical activity · 2012Article
- Fetal programming of body composition, obesity, and metabolic function: the role of intrauterine stress and stress biology.Journal of nutrition and metabolism · 2012Article
- An overview of mongenic and syndromic obesities in humans.Pediatric blood & cancer · 2012Article
- Introduction to genetics and childhood obesity: relevance to nursing practice.Biological research for nursing · 2011Review
- Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings.Current opinion in endocrinology, diabetes, and obesity · 2010Review
- Chronic health conditions in childhood cancer survivors: is it all treatment-related--or do genetics play a role?Journal of general internal medicine · 2009Review
- Obesity in the 21st century.Environmental health perspectives · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a complex disease that involves interactions between environmental and genetic factors. Obesity results from an imbalance between food intake and energy expenditure over several years. The genetic approach both in animal models and in humans has allowed immense progress in the understanding of body weight regulation. Monogenic forms of obesity in humans have been characterized and result from mutations in genes involved in the central pathways of food intake regulation. However, these cases are extremely rare and generally obesity must be considered as a complex polygenic disease involving interactions between multiple genes and the environment. Numerous studies, including studies in children, have tried to identify "susceptibility" genes. At present, the results are not conclusive inasmuch as they are highly variable between studies and because the relative risk associating a specific gene allele and obesity remains low. Thus, it seems highly premature to genotype obese patients on a large scale for predictive testing. When specific pharmacological treatments based on recent discoveries become available, however, genetic testing could help discriminate between the subtypes of obesity that may respond differentially to treatment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.