ArticleStroke2003
Aortic stiffness is an independent predictor of fatal stroke in essential hypertension.
Article in Stroke, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 315 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
Validation of Photoplethysmography Device for the Measurement of Aortic Pulse Wave Velocity Against Carotid-Femoral Values From Piezoelectric Sensors
Who cites it
315 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2015Guideline
- Efficacy and safety of calcium channel blocker/diuretics combination therapy in hypertensive patients: a meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2015Pooled it
- Impact of Blood Pressure Self-Management on Vascular Remodeling After Hypertensive Pregnancy.Hypertension (Dallas, Tex. : 1979) · 2025Trial
- Is GFR decline induced by SGLT2 inhibitor of clinical importance?Cardiovascular diabetology · 2024Trial
- Influence of baseline arterial stiffness on effects of intensive compared with standard blood pressure control: a post hoc analysis of the STEP trial.BMC medicine · 2022Trial
- Central systolic blood pressure and aortic stiffness response to dietary sodium in young and middle-aged adults.Journal of the American Society of Hypertension : JASH · 2017Trial
- Trial
- Risk Stratification of Patients with Peripheral Arterial Disease and Abdominal Aortic Aneurysm Using Aortic Augmentation Index.PloS one · 2015Trial
- Cardio-ankle vascular index and subclinical heart disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Trial
- Pulsatility index: Insights into post-stroke haemodynamics.Neuroscience insights · 2026Review
- Sex-specific distribution of the uric acid-to-HDL cholesterol ratio and its association with arterial stiffness in a Japanese health check-up population: a cross-sectional analysis.Frontiers in endocrinology · 2026Article
- Association of Increased Central Arterial Stiffness With BBB Disruption in Patients With Reversible Cerebral Vasoconstriction Syndrome.Neurology · 2025Article
- A Study on Evaluating Cardiovascular Diseases Using PPG Signals.Bioengineering (Basel, Switzerland) · 2025Article
- Sex-Specific Differences in Subclinical Organ Damage and Cardiovascular Risk Stratification Among Patients Classified by the Presence of Coronary Artery Disease and Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Blood Pressure Variability in Hypertension: A Rehabilitation Perspective.Journal of cardiovascular development and disease · 2025Review
- Sacubitril/Valsartan: A Game-changer for Hypertensive Patients Beyond Blood Pressure Control?Internal medicine (Tokyo, Japan) · 2025Article
- Arterial Stiffness and Markers of Atrial Myopathy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025Article
- Measurement of pressure dependent variations in local pulse wave velocity within a cardiac cycle from forward travelling pulse waves.Scientific reports · 2025Article
- Endothelial dysfunction in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: current knowledge and novel biomarkers.Frontiers in endocrinology · 2025Review
- Association between estimated pulse wave velocity and stroke in middle-aged and elderly Chinese: A nationwide cohort study.PloS one · 2025Article
255 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePulse pressure is a stronger predictor of cardiovascular events than systolic or diastolic blood pressure in large cohorts of French and North American patients. However, its influence on stroke is controversial. Large-artery stiffness is the main determinant of pulse pressure. The influence of arterial stiffness on the occurrence of stroke has never been demonstrated. Our aim was to establish the relationship between aortic stiffness and stroke death in hypertensive patients.
methodsWe included, in a longitudinal study, 1715 essential hypertensive patients who had a measurement of arterial stiffness at entry (ie, between 1980 and 2001) and no overt cardiovascular disease or symptoms. Mean follow-up was 7.9 years. At entry, aortic stiffness was assessed from the carotid-femoral pulse wave velocity. A Cox proportional hazard regression model was used to estimate the relative risk (RR) of stroke and coronary deaths.
resultsMean+/-SD age at entry was 51+/-13 years. Twenty-five fatal strokes and 35 fatal coronary events occurred. Pulse wave velocity significantly predicted the occurrence of stroke death in the whole population. There was a RR increase of 1.72 (95% CI, 1.48 to 1.96; P<0.0001) for each SD increase in pulse wave velocity (4 m/s). The predictive value of pulse wave velocity remained significant (RR=1.39 [95% CI, 1.08 to 1.72]; P=0.02) after full adjustment for classic cardiovascular risk factors, including age, cholesterol, diabetes, smoking, mean blood pressure, and pulse pressure. In this population, pulse pressure significantly predicted stroke in univariate analysis, with a RR increase of 1.33 (95% CI, 1.16 to 1.51) for each 10 mm Hg of pulse pressure (P<0.0001) but not after adjustment for age (RR=1.19 [95% CI, 0.96 to 1.47]; P=0.10).
conclusionsThis study provides the first evidence, in a longitudinal study, that aortic stiffness is an independent predictor of fatal stroke in patients with essential hypertension.
Indexed as
Identifiers
12677025What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.