ArticleInfection and immunity2003
Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis.
Article in Infection and immunity, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Research advances and public health strategies in China on WHO priority fungal pathogens.Mycology · 2025Review
- Aspergillus fumigatus escape mechanisms from its harsh survival environments.Applied microbiology and biotechnology · 2024Review
- Pathogenicity and virulence ofVirulence · 2023Review
- The Rheb GTPase promotes pheromone blindness via a TORC1-independent pathway in the phytopathogenic fungus Ustilago maydis.PLoS genetics · 2022Article
- Article
- Nitrogen, Iron and Zinc Acquisition: Key Nutrients toJournal of fungi (Basel, Switzerland) · 2021Review
- Review
- The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride.PloS one · 2021Article
- Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019Review
- Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.Molecular microbiology · 2018Review
- Article
- Evolutionary Conservation of the Components in the TOR Signaling Pathways.Biomolecules · 2017Review
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- Comparative Genomics of Sibling Species ofFrontiers in microbiology · 2017Article
- Aspergillosis and stem cell transplantation: An overview of experimental pathogenesis studies.Virulence · 2016Review
- Developmental regulators in Aspergillus fumigatus.Journal of microbiology (Seoul, Korea) · 2016Review
- The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance.Journal of microbiology (Seoul, Korea) · 2016Review
- Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets.Frontiers in microbiology · 2015Article
- Aspergillus fumigatus and related species.Cold Spring Harbor perspectives in medicine · 2014Review
- Nitrogen source-dependent capsule induction in human-pathogenic cryptococcus species.Eukaryotic cell · 2013Article
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6 authors.
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Abstract
Aspergillus fumigatus is the predominant mold pathogen in patients who lack functional innate immunity. The A. fumigatus rhbA gene was first identified as a transcript that was upregulated when the organism was grown in the presence of mammalian cells. To gain insight into the function of rhbA in the growth and pathogenesis of A. fumigatus, we constructed a strain that lacks a functional rhbA gene. The Delta rhbA mutant showed a significant reduction in virulence compared to the virulence of the wild type in a mouse model of invasive aspergillosis. Complementation of the deletion with the wild-type gene restored full virulence. Although the Delta rhbA mutant grew as well as the wild type on solid medium containing the rich nitrogen source ammonium, the growth of the mutant was impaired on medium containing poor nitrogen sources. Like the Saccharomyces cerevisiae rhb1 mutant, the Delta rhbA mutant exhibited increased uptake of arginine. In addition, the Delta rhbA strain underwent asexual development in submerged cultures, even under ammonium-excess conditions. Growth of the mutant with poor nitrogen sources eliminated both the arginine uptake and submerged asexual development phenotypes. The mutant showed enhanced sensitivity to the TOR kinase inhibitor rapamycin. These findings establish the importance of rhbA for A. fumigatus virulence and suggest a role for rhbA in nutrient sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.