ArticleMolecular and cellular biology2003
Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate change.Genes & development · 2025Article
- Nuclear receptor coactivator 6 is a critical regulator of NLRP3 inflammasome activation and gouty arthritis.Cellular & molecular immunology · 2024Article
- UBE3A Suppresses Overnutrition-Induced Expression of the Steatosis Target Genes of MLL4 by Degrading MLL4.Hepatology (Baltimore, Md.) · 2019Article
- Liver X receptors link lipid metabolism and inflammation.FEBS letters · 2017Review
- Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor.The Journal of clinical investigation · 2015Article
- Transient replication of Hepatitis C Virus sub-genomic RNA in murine cell lines is enabled by miR-122 and varies with cell passage.PloS one · 2014Article
- MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms.International journal of biological sciences · 2011Article
- PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1.Nuclear receptor signaling · 2010Review
- Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis.The Journal of biological chemistry · 2010Article
- Coactivators in PPAR-Regulated Gene Expression.PPAR research · 2010Article
- Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Roles of histone H3-lysine 4 methyltransferase complexes in NR-mediated gene transcription.Progress in molecular biology and translational science · 2009Review
- Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development.Nuclear receptor signaling · 2008Review
- Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice.Molecular and cellular biology · 2007Article
- Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2.Molecular and cellular biology · 2006Article
- Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression.Molecular and cellular biology · 2004Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activating signal cointegrator 2 (ASC-2), a cancer-amplified transcriptional coactivator of nuclear receptors and many other transcription factors, contains two LXXLL-type nuclear receptor interaction domains. Interestingly, the second LXXLL motif is highly specific to the liver X receptors (LXRs). In cotransfection, DN2, an ASC-2 fragment encompassing this motif, exerts a potent dominant-negative effect on transactivation by LXRs, which is rescued by ectopic coexpression of the full-length ASC-2 but not by other LXXLL-type coactivators, such as SRC-1 and TRAP220. In contrast, DN2/m, in which the LXXLL motif is mutated to LXXAA to abolish the interactions with LXRs, is without any effect. Accordingly, expression of DN2, but not DN2/m, in transgenic mice results in phenotypes that are highly homologous to those previously observed with LXRalpha(-/-) mice, including a rapid accumulation of large amounts of cholesterol and down-regulation of the known lipid-metabolizing target genes of LXRalpha in the liver upon being fed a high-cholesterol diet. These results identify ASC-2 as a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.