Evidence map›Paper›PMID 12821276›Full record

ArticleAnnals of epidemiology2003

Impact of antidiabetic medications on physical and cognitive functioning of older Mexican Americans with diabetes mellitus: a population-based cohort study.

Jasmanda H Wu, Mary N Haan, Jersey Liang, Debashis Ghosh, Hector M Gonzalez, William H Herman

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Annals of epidemiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06072963 (Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06072963 phase2recruitingstarted 2024, after this paper: background citation

Combination of Intranasal Insulin With Oral Semaglutide to Improve Cognition and Cerebral Blood Flow: a Feasibility Study

Ran2024Enrolled80Registered outcomes15Posted comparisons0ConditionsAlzheimer Disease, Metabolic Syndrome, Mild Cognitive ImpairmentArmsIntranasal insulin, Intranasal insulin placebo, semaglutide, Semaglutide placebo
PMID 36871874PMID 29687620PMID 17848936PMID 33831607PMID 33585983PMID 33461618PMID 33222922PMID 33044181PMID 32982937PMID 32716707PMID 32588967PMID 32568367other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Antidiabetic therapies and Alzheimer disease.Dialogues in clinical neuroscience · 2019
    Review
  10. Review
  11. Observational
  12. Article
  13. Diabetes mellitus and cognitive impairments.World journal of diabetes · 2016
    Review
  14. Review
  15. Article
  16. Type 2 diabetes and cognitive compromise: potential roles of diabetes-related therapies.Endocrinology and metabolism clinics of North America · 2013
    Review
  17. Review
  18. Review
  19. Article
  20. Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 1.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jasmanda H WuUniversity of Michigan, School of Public Health, Epidemiology, Ann Arbor, MI 48109, USA.
Mary N Haan
Jersey Liang
Debashis Ghosh
Hector M Gonzalez
William H Herman
University of Michigan–Ann Arbor · USMichigan Medicine · US

Funding

EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICSR01AG012975 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1997 to 2005
$5.8M
Diabetes in older Latinos, stress and brain changesR01DK060753 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2002 to 2004
$1.4M
NIA NIH HHS R01 AG012975NIA NIH HHS R03 AG033751NIDDK NIH HHS R01 DK060753PHS HHS NIA 12975
6 · The paper itself

Abstract

purposeThe current study was designed to evaluate the utility of antidiabetic medications in affecting changes in physical and cognitive functioning among older Mexican Americans with diabetes over a 2-year period.

methodsA longitudinal analysis with repeated measurements between 1999 and 2001 was performed in a cohort of Mexican Americans, 60 or older, in the SALSA Project. Statistical analysis was conducted using a generalized estimating equation.

resultsFor subjects with diagnosed diabetes </= 5 years (N = 381), there was less decline in physical and cognitive functioning over 2 years among subjects on treatment, compared to those without treatment. For subjects with diagnosed diabetes of 5+ years (N = 337), the effect of antidiabetic medications was more significant in preventing the decline in physical and cognitive functioning (ADL: mean in log scale = -0.10, 95% CI = -0.16, -0.04, 3MS: mean = 6.35, 95% CI = 3.23, 9.48). Combination therapy of antidiabetic agents appeared to be more effective than monotherapy in preventing the decline in physical and cognitive functioning for subjects.

conclusionsAntidiabetic drugs appear to be useful in alleviating the decline in physical and cognitive functioning among older Mexican Americans with diabetes, especially for those with a longer duration of the disease.

Indexed as

Activities of Daily LivingMexican AmericansAgedAged, 80 and overAgingCognitionCohort StudiesHumansHypoglycemic AgentsLongitudinal StudiesMiddle AgedQuality of LifeHypoglycemic Agents

Identifiers

PMID12821276
OpenAlexW2580810426

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.