ArticleThe Journal of physiology2003
Non-contractile cells with thin processes resembling interstitial cells of Cajal found in the wall of guinea-pig mesenteric arteries.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Hypertension Induced Morphological and Physiological Changes in Cells of the Arterial Wall.American journal of hypertension · 2018Review
- Extragastrointestinal stromal tumor of the inferior vena cava: a case report.Surgical case reports · 2017Article
- Morphological evidence of telocytes in mice aorta.Chinese medical journal · 2015Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder.British journal of pharmacology · 2012Article
- Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries.Journal of cellular and molecular medicine · 2012Article
- Potentiation of carbachol-induced detrusor smooth muscle contractions by beta-adrenoceptor activation.European journal of pharmacology · 2009Article
- Apoptotic cell death of human interstitial cells of Cajal.Neurogastroenterology and motility · 2009Article
- Inherent rhythmicity and interstitial cells of Cajal in a frog vein.Journal of biosciences · 2008Article
- Voltage-dependent Ca Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2008Article
- Calcium events in smooth muscles and their interstitial cells; physiological roles of sparks.The Journal of physiology · 2006Review
- TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells.The Journal of comparative neurology · 2004Article
- Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach.Journal of cellular and molecular medicineArticle
- Close relation of arterial ICC-like cells to the contractile phenotype of vascular smooth muscle cell.Journal of cellular and molecular medicineArticle
- Interstitial cells of Cajal in pancreas.Journal of cellular and molecular medicineArticle
- Novel type of interstitial cell (Cajal-like) in human fallopian tube.Journal of cellular and molecular medicineArticle
- Interstitial cells in the vasculature.Journal of cellular and molecular medicineReview
- Interstitial cells from rat middle cerebral artery belong to smooth muscle cell type.Journal of cellular and molecular medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Arterial interstitial cells of Cajal (ICC)-like cells (AIL cells) with a multipolar, irregular, elongated shape and with numerous thin (often less than 1 microm), sometimes branching, processes with lengths up to approximately 60 microm were isolated enzymatically from 1st to 7th order branches of guinea-pig mesenteric artery. Some of the processes of AIL cells were growing (average speed approximately 0.15 microm min-1) and their growth was blocked by 10 microM latrunculin B, an inhibitor of actin polymerisation. Staining with BODIPY phalloidin, a fluorescent dye selective for F-actin, showed the presence of F-actin in the processes of AIL cells. Voltage clamp of single AIL cells revealed an inward current that was four times more dense than in myocytes and was abolished by 10 microM nicardipine, and an outward current carried exclusively by potassium ions that was reduced by 1 mM 4-aminopyridine and/or 100 nM iberiotoxin but unaffected by 10 nM dendrotoxin-K. Imaging of intracellular ionised calcium with fluo-4 using a laser scanning confocal microscope showed local or global calcium transients lasting several seconds in approximately 28 % of AIL cells. When membrane current was recorded simultaneously, the calcium transients were found to correspond to long-lasting transient outward currents, which occurred at potentials positive to -40 mV. Unlike myocytes, AIL cells did not contract in response to 1 mM caffeine or 5 microM noradrenaline, although they responded with a [Ca2+]i increase. The segments of intact arteries did not stain for c-kit, a marker of ICCs. Single AIL cells stained positive for vimentin, desmin and smooth muscle myosin. The presence of ICC-like cells is demonstrated for the first time in the media of resistance arteries.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.