ArticleThe EMBO journal2003
Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 74 citations in OpenAlex.
- ER sensing of lipid metabolism drives PRA family-dependent regulation of COPII vesicle transport.Nature communications · 2026Article
- Beyond Vesicular Traffic: The ERES as the Gateway for Biosynthetic Secretion.Sub-cellular biochemistry · 2026Review
- Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway.Nature reviews. Molecular cell biology · 2025Review
- UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation.Nature communications · 2025Article
- Lipid synthesis and transport are coupled to regulate membrane lipid dynamics in the endoplasmic reticulum.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Review
- A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking.Nature communications · 2019Article
- PERK-Mediated Unfolded Protein Response Activation and Oxidative Stress in PARK20 Fibroblasts.Frontiers in neuroscience · 2019Article
- Lysophospholipids Facilitate COPII Vesicle Formation.Current biology : CB · 2018Article
- Overexpression of Cu-Zn SOD inOncotarget · 2018Article
- Clickable Substrate Mimics Enable Imaging of Phospholipase D Activity.ACS central science · 2017Article
- Molecular regulation of lysophosphatidic acid receptor 1 trafficking to the cell surface.Cellular signalling · 2014Article
- Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.The Journal of biological chemistry · 2014Review
- Phosphatidic acid phospholipase A1 mediates ER-Golgi transit of a family of G protein-coupled receptors.The Journal of cell biology · 2014Article
- A cascade of ER exit site assembly that is regulated by p125A and lipid signals.Journal of cell science · 2014Article
- COPII - a flexible vesicle formation system.Current opinion in cell biology · 2013Article
- A role for phospholipase D3 in myotube formation.PloS one · 2012Article
- COPII and the regulation of protein sorting in mammals.Nature cell biology · 2011Review
- Protein export at the ER: loading big collagens into COPII carriers.The EMBO journal · 2011Review
- Links between lipid homeostasis, organelle morphodynamics and protein trafficking in eukaryotic and plant secretory pathways.Plant cell reports · 2011Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The small GTPase Sar1p controls the assembly of the cytosolic COPII coat that mediates export from the endoplasmic reticulum (ER). Here we demonstrate that phospholipase D (PLD) activation is required to support COPII-mediated ER export. PLD activity by itself does not lead to the recruitment of COPII to the membranes or ER export. However, PLD activity is required to support Sar1p-dependent membrane tubulation, the subsequent Sar1p-dependent recruitment of Sec23/24 and Sec13/31 COPII complexes to ER export sites and ER export. Sar1p recruitment to the membrane is PLD independent, yet activation of Sar1p is required to stimulate PLD activity on ER membranes, thus PLD is temporally regulated to support ER export. Regulated modification of membrane lipid composition is required to support the cooperative interactions that enable selective transport, as we demonstrate here for the mammalian COPII coat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.