ArticleJapanese journal of cancer research : Gann1992
Activation of the mouse proliferating cell nuclear antigen gene promoter by adenovirus type 12 E1A proteins.
Article in Japanese journal of cancer research : Gann, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Transcription factor decoy oligonucleotide-based therapeutic strategy for renal disease.Clinical and experimental nephrology · 2007Review
- Inhibition of mesangial cell proliferation by E2F decoy oligodeoxynucleotide in vitro and in vivo.The Journal of clinical investigation · 1998Article
- Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F.Gene expression · 1996Article
- Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.Molecular and cellular biology · 1995Article
- A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Transcriptional regulation of DNA replication-related genes in cell growth, differentiation and oncogenesis.Japanese journal of cancer research : Gann · 1994Review
- MCB elements and the regulation of DNA replication genes in yeast.Current genetics · 1993Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A plasmid carrying the 5'-flanking region (-1584 to +47 with respect to the transcription initiation site) of the mouse proliferating cell nuclear antigen (PCNA) gene was fused with the chloramphenicol acetyltransferase (CAT) gene, and then cotransfected into mouse N18TG2 cells with expression plasmids for the adenovirus type 12 E1 genes. Expression of E1A gene products elevated the CAT expression by 5- to 9-fold, but expression of the E1B gene product did not. RNase protection analysis revealed that the activation of the PCNA gene promoter by E1A was at the transcription step. Both the 13S E1A and the 12S E1A activated the PCNA gene promoter, indicating that the activation domain of E1A resides in a common region(s) of 13S and 12S E1A products. The major target region of E1A was mapped within the 68 base-pair region (-21 to +47) of the PCNA gene, which includes consensus sequences for transcription factors PEA3 and E2F, although the upstream region (-83 to -21) including ATF(CREB)-binding consensus had an additional effect in the transactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.