ArticleBritish journal of pharmacology2003
FK506 potentiates NGF-induced neurite outgrowth via the Ras/Raf/MAP kinase pathway.
Article in British journal of pharmacology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
- Clinical applications of tacrolimus in the treatment of ocular diseases: a narrative literature review.International ophthalmology · 2025Review
- Impact of SOCE Abolition by ORAI1 Knockout on the Proliferation, Adhesion, and Migration of HEK-293 Cells.Cells · 2021Article
- The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.Bosnian journal of basic medical sciences · 2018Article
- Article
- The effects of FK1706 on nerve regeneration and bladder function recovery following an end-to-side neurorrhaphy in rats.Oncotarget · 2017Article
- Effect Of combining FK506 and neurotrophins on neurite branching and elongation.Muscle & nerve · 2017Article
- TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain.Pflugers Archiv : European journal of physiology · 2014Article
- Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro.Peptides · 2014Article
- Rapamycin promotes Schwann cell migration and nerve growth factor secretion.Neural regeneration research · 2014Article
- Neurotrophic natural products: chemistry and biology.Angewandte Chemie (International ed. in English) · 2014Review
- Article
- Combined treatment with FK506 and nerve growth factor for spinal cord injury in rats.Experimental and therapeutic medicine · 2013Article
- Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells.BMC complementary and alternative medicine · 2013Article
- Article
- The neuroregenerative mechanism mediated by the Hsp90-binding immunophilin FKBP52 resembles the early steps of neuronal differentiation.British journal of pharmacology · 2012Article
- FK506 neuroprotection after cavernous nerve injury is mediated by thioredoxin and glutathione redox systems.The journal of sexual medicine · 2011Article
- Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth.Journal of neurochemistry · 2010Article
- Article
- Role of calcineurin in the regulation of human lung mast cell and basophil function by cyclosporine and FK506.British journal of pharmacology · 2007Article
- A multiplexed proteomics approach to differentiate neurite outgrowth patterns.Journal of neuroscience methods · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve growth factor (NGF) and other members of the neurotrophin family are critical for the survival and differentiation of neurons within the peripheral and central nervous systems. Neurophilin ligands, including FK506, potentiate NGF-induced neurite outgrowth in several experimental models, although the mechanism of this potentiation is unclear. Therefore, we tested which signaling pathways were involved in FK506-potentiated neurite outgrowth in SH-SY5Y neuroblastoma cells using specific pharmacological inhibitors of various signaling molecules. Inhibitors of Ras (lovastatin), Raf (GW5074), or MAP kinase (PD98059 and U0126) blocked FK506 activity, as did inhibitors of phospholipase C (U73122) and phosphatidylinositol 3' kinase (LY294002). Protein kinase C inhibitors (Go6983 and Ro31-8220) slightly but significantly inhibited neurite outgrowth, whereas inhibitors of p38 MAPK (SB203580) or c-Jun N-terminal kinase (SP600125) had no effect. These data suggest that FK506 potentiates neurite outgrowth through the Ras/Raf/MAP kinase signaling pathway downstream of phospholipase C and phosphatidylinositol 3' kinase.
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