ArticleBritish journal of pharmacology2004
Comparison of U46619-, endothelin-1- or phenylephrine-induced changes in cellular Ca2+ profiles and Ca2+ sensitisation of constriction of pressurised rat resistance arteries.
Article in British journal of pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Regulated extravascular microenvironmentBioactive materials · 2023Article
- NLRP3 activation contributes to endothelin-1-induced erectile dysfunction.Journal of cellular and molecular medicine · 2023Article
- Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Aging alters spontaneous and neurotransmitter-mediated CaMicrocirculation (New York, N.Y. : 1994) · 2020Article
- Vasoconstrictor stimulus determines the functional contribution of myoendothelial feedback to mesenteric arterial tone.The Journal of physiology · 2018Article
- A multiscale active structural model of the arterial wall accounting for smooth muscle dynamics.Journal of the Royal Society, Interface · 2018Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed.Purinergic signalling · 2014Article
- Endothelin-1-induced vasoconstriction does not require intracellular Ca²⁺ waves in arteries from rats exposed to intermittent hypoxia.American journal of physiology. Heart and circulatory physiology · 2014Article
- Hypoxic pulmonary vasoconstriction.Physiological reviews · 2012Review
- Pressure-dependent contribution of Rho kinase-mediated calcium sensitization in serotonin-evoked vasoconstriction of rat cerebral arteries.The Journal of physiology · 2010Article
- Calcineurin-NFAT signaling is involved in phenylephrine-induced vascular smooth muscle cell proliferation.Acta pharmacologica Sinica · 2009Article
- Smooth muscle cell calcium activation mechanisms.The Journal of physiology · 2008Review
- Vasomotion dynamics following calcium spiking depend on both cell signalling and limited constriction velocity in rat mesenteric small arteries.Journal of cellular and molecular medicine · 2008Article
- Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment.Biophysical journal · 2007Article
- Rhythmicity in arterial smooth muscle.The Journal of physiology · 2005Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In pressurised rat mesenteric small arteries (50 mmHg), we examined the effects of stimulation with U46619, endothelin-1 (ET-1) or phenylephrine (PE) on changes in vessel diameter, global [Ca(2+)](i), individual smooth muscle cell [Ca(2+)](i) and Ca(2+)-sensitisation of contraction. 2. U46619 or ET-1 gave tonic diameter reductions, whereas PE-stimulated vessels gave tonic contractions or initial vasoconstrictions followed by diameter oscillations. Global [Ca(2+)](i) changes were transient for each agonist, with tonic constrictions being accompanied by maintained submaximal global [Ca(2+)](i) levels. 3. U46619, ET-1 or PE tonic constrictions were accompanied by apparently asynchronous [Ca(2+)](i) waves in individual smooth muscle cells of the vessel wall, as examined by confocal fluorescent microscopy. In vessels exhibiting vasomotion to PE, some apparent synchrony of activation of individual cells was evident; however, this was incomplete with many cells responding out of phase with their neighbours. 4. In alpha-toxin-permeabilised preparations, agonist-induced Ca(2+)-sensitisation of constriction at submaximal Ca(2+) (pCa6.7) in the presence of GTP was greater with U46619 or ET than PE. 5. We conclude that, in pressurised mesenteric arteries, (i) a general feature of receptor-coupled constriction is the generation of periodic smooth muscle [Ca(2+)](i) waves; (ii) complete synchrony of Ca(2+) oscillations between smooth muscle cells is not a prerequisite for receptor-coupled vasomotion; (iii) varied Ca(2+)-sensitising actions of agonists may partly determine tonic or phasic vessel responses to different stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.