ArticleMolecular and cellular biology2004
A functional domain of Dof that is required for fibroblast growth factor signaling.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo.Scientific reports · 2021Article
- What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins.Development genes and evolution · 2020Article
- Receptor tyrosine kinases in Drosophila development.Cold Spring Harbor perspectives in biology · 2013Review
- Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster.International journal of molecular sciences · 2013Article
- Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain.Development (Cambridge, England) · 2012Article
- The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization.Genes and immunity · 2012Article
- FGFs: Neurodevelopment's Jack-of-all-Trades - How Do They Do it?Frontiers in neuroscience · 2011Article
- A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission.Molecular and cellular biology · 2010Article
- Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function.EMBO reports · 2006Article
- A screen for genes that influence fibroblast growth factor signal transduction in Drosophila.Genetics · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal transduction by fibroblast growth factor (FGF) receptors in Drosophila depends upon the intracellular protein Dof, which has been proposed to act downstream of the receptors and upstream of Ras. Dof is the product of a fast-evolving gene whose vertebrate homologs, BCAP and BANK, are involved in signaling downstream of the B-cell receptor. Mapping functional domains within Dof revealed that neither of its potential interaction motifs, the ankyrin repeats and the coiled coil, is essential for the function of Dof. However, we have identified a region within the N terminus of the protein with similarity to BCAP and BANK, which we refer to as the Dof, BCAP, and BANK (DBB) motif, that it is required for FGF-dependent signal transduction and is necessary for efficient interaction of Dof with the FGF receptor Heartless. In addition, we demonstrate that Dof is phosphorylated in the presence of an activated FGF receptor and that tyrosine residues could contribute to the function of the molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.