Evidence mapPaperPMID 15007111Full record

ArticleThe New England journal of medicine2004

Intensive statin therapy--a sea change in cardiovascular prevention.

Eric J Topol

Registry-linked trialAbstract readEditorialComment
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01334671 (The Clinical Effect of Intensive Statin Therapy in STEMI), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01334671 phase3unknown statusstarted 2011, after this paper: background citation

The Clinical Effect of Intensive Statin Therapy in STEMI(ST-elevated Myocardial Infarction) Patients Before Emergency PCI(Percutaneous Coronary Intervention)

Ran2011Enrolled150Registered outcomes5Posted comparisons0ConditionsST-elevation Myocardial Infarction, (STEMI)ArmsAtorvastatin
Open the trial in the graph
3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. The many roles of statins in ischemic stroke.Current neuropharmacology · 2014
    Article
  5. Hypertriglyceridemia-induced recurrent acute pancreatitis: A case-based review.Indian journal of endocrinology and metabolism · 2012
    Article
  6. Article
  7. Article
  8. 'Me-Too' Innovation in Pharmaceutical Markets.Forum for health economics & policy · 2009
    Article
  9. Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008
    Article
  10. Review
  11. Review
  12. Hypertriglyceridemia: its etiology, effects and treatment.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2007
    Review
  13. Dose-dependency in pleiotropic effects of atorvastatin.The International journal of angiology : official publication of the International College of Angiology, Inc · 2007
    Article
  14. Atorvastatin inhibits inflammatory hypernociception.British journal of pharmacology · 2006
    Article
  15. Article
  16. Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells.Proceedings of the National Academy of Sciences of the United States of America · 2006
    Article
  17. Brain cholesterol turnover required for geranylgeraniol production and learning in mice.Proceedings of the National Academy of Sciences of the United States of America · 2006
    Article
  18. Article
  19. Article
  20. Statins and stroke prevention.Current atherosclerosis reports · 2005
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Eric J Topol

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angina, UnstableAtorvastatinCardiovascular DiseasesCholesterol, LDLC-Reactive ProteinHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMyocardial InfarctionPravastatinPyrrolesAtorvastatinCholesterol, LDLC-Reactive ProteinHeptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsPravastatinPyrroles

Identifiers

PMID15007111

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.