SynthesisJournal of general internal medicine2004
Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease.
Synthesis in Journal of general internal medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Effects of fish oil on serum lipid profile in dialysis patients: a systematic review and meta-analysis of randomized controlled trials.Lipids in health and disease · 2014Pooled it
- Influence of vitamin E supplementation on glycaemic control: a meta-analysis of randomised controlled trials.PloS one · 2014Pooled it
- Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2013Pooled it
- Secondary prevention of ischaemic cardiac events.BMJ clinical evidence · 2011Pooled it
- Primary prevention of CVD: diet and weight loss.BMJ clinical evidence · 2007Pooled it
- Vitamin E might increase risk of death.Canadian family physician Medecin de famille canadien · 2005Pooled it
- Changes in Morphological, Physiological and Phytochemical Traits of Different Dill (Molecules (Basel, Switzerland) · 2024Article
- The Efficacy of Vitamins in the Prevention and Treatment of Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment.Current cardiology reports · 2020Review
- Clinical Advances in Immunonutrition and Atherosclerosis: A Review.Frontiers in immunology · 2019Review
- Impact of Particulate Air Pollution on Cardiovascular Health.Current allergy and asthma reports · 2018Review
- Study of respiratory chain dysfunction in heart disease.Journal of cardiovascular and thoracic research · 2018Review
- Antioxidants in Translational Medicine.Antioxidants & redox signaling · 2015Review
- Focus on Pivotal Role of Dietary Intake (Diet and Supplement) and Blood Levels of Tocopherols and Tocotrienols in Obtaining Successful Aging.International journal of molecular sciences · 2015Review
- Regulatory metabolites of vitamin E and their putative relevance for atherogenesis.Redox biology · 2014Review
- The NOX toolbox: validating the role of NADPH oxidases in physiology and disease.Cellular and molecular life sciences : CMLS · 2012Review
- Functional foods and nutraceuticals in the primary prevention of cardiovascular diseases.Journal of nutrition and metabolism · 2012Article
- Coronary heart disease prevention: nutrients, foods, and dietary patterns.Clinica chimica acta; international journal of clinical chemistry · 2011Review
- Good stress, bad stress--the delicate balance in the vasculature.Deutsches Arzteblatt international · 2009Review
- Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality.American journal of epidemiology · 2009Article
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.
designSystematic review of placebo-controlled randomized controlled trials; meta-analysis where justified. MEASUREMENTS AND MAIN
resultsEighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.
conclusionsThere is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.