ArticleProceedings of the National Academy of Sciences of the United States of America2004
Mitochondrial DNA ligase in Crithidia fasciculata.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Aurora kinase protein family in Trypanosoma cruzi: Novel role of an AUK-B homologue in kinetoplast replication.PLoS neglected tropical diseases · 2019Article
- U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA.Mitochondrion · 2015Article
- Highly precise and developmentally programmed genome assembly in Paramecium requires ligase IV-dependent end joining.PLoS genetics · 2011Article
- A second mitochondrial DNA primase is essential for cell growth and kinetoplast minicircle DNA replication in Trypanosoma brucei.Eukaryotic cell · 2011Article
- A mitochondrial DNA primase is essential for cell growth and kinetoplast DNA replication in Trypanosoma brucei.Molecular and cellular biology · 2010Article
- Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase.RNA (New York, N.Y.) · 2009Article
- Mitochondrial origin-binding protein UMSBP mediates DNA replication and segregation in trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Identification of new kinetoplast DNA replication proteins in trypanosomatids based on predicted S-phase expression and mitochondrial targeting.Eukaryotic cell · 2007Article
- Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast.Molecular microbiology · 2007Article
- Development of a pharmacodynamic screening model with Crithidia fasciculata.Wiener klinische Wochenschrift · 2006Article
- Cell cycle-dependent localization and properties of a second mitochondrial DNA ligase in Crithidia fasciculata.Eukaryotic cell · 2006Article
- Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates.Current genetics · 2005Review
- A type II ribonuclease H from Leishmania mitochondria: an enzyme essential for the growth of the parasite.Molecular and biochemical parasitology · 2005Article
- Mitochondrial DNA ligases of Trypanosoma brucei.Eukaryotic cell · 2005Article
- The developmental cell biology of Trypanosoma brucei.Journal of cell science · 2005Review
- Closing the gaps in kinetoplast DNA network replication.Proceedings of the National Academy of Sciences of the United States of America · 2004Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
Kinetoplast DNA (kDNA), the form of mitochondrial DNA in trypanosomatids, consists of thousands of interlocked circular DNAs organized into a compact disk structure. A type II DNA topoisomerase, a DNA polymerase beta, and a structure-specific endonuclease have been localized to antipodal sites flanking the kDNA disk along with nascent DNA minicircles. We have cloned a gene (LIG k) encoding a mitochondrial DNA ligase in the trypanosomatid Crithidia fasciculata, and we show that an epitope-tagged form of the ligase colocalizes with the other replication proteins at the antipodal sites and also at the two faces of the kDNA disk. DNA LIG k becomes adenylated in reactions with ATP, and the adenylate moiety is removed by incubation with pyrophosphate or nicked DNA. The ligase interacts physically with the beta polymerase and is proposed to be involved in the repair of gaps in the newly synthesized minicircles. In yeast and mammals, a single gene encodes both nuclear and mitochondrial forms of DNA ligase. The LIG K protein sequence has low similarity to mitochondrial DNA ligases in other eukaryotes and is distinct from the C. fasciculata nuclear DNA ligase (LIG I).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.