ReviewJournal of psychiatry & neuroscience : JPN2004
Gene-environment interaction and the genetics of depression.
Review in Journal of psychiatry & neuroscience : JPN, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis.Journal of affective disorders · 2018Pooled it
- Pooled it
- Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism.International journal of impotence research · 2017Trial
- Sex-specific neurodevelopmental pathways to depressive symptoms.Molecular psychiatry · 2026Article
- The intersection between race/ethnicity and adverse childhood experiences and its association with depression.Social psychiatry and psychiatric epidemiology · 2026Article
- The role of gene-environment interactions in endocrine-sensitive life stages for shaping mental health: focus on the RE-MEND project.Frontiers in psychiatry · 2026Review
- Genomic risk prediction for depression in a large prospective study of older adults of European descent.Molecular psychiatry · 2025Article
- Intergenerational continuity of depressive symptoms: genetic and environmental pathways.Psychological medicine · 2025Article
- Review
- Not Just a Mood Disorder─Is Depression a Neurodevelopmental, Cognitive Disorder? Focus on Prefronto-Thalamic Circuits.ACS chemical neuroscience · 2024Review
- Article
- Association Between MTHFR rs17367504 Polymorphism and Major Depressive Disorder in Taiwan: Evidence for Effect Modification by Exercise Habits.Frontiers in psychiatry · 2022Article
- Gene × environment interaction in major depressive disorder.World journal of clinical cases · 2021Review
- Neuroinflammatory Basis of Depression: Learning From Experimental Models.Frontiers in cellular neuroscience · 2021Review
- PPARD May Play a Protective Role for Major Depressive Disorder.PPAR research · 2021Article
- Depression and prostate cancer: implications for urologists and oncologists.Nature reviews. Urology · 2020Review
- International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic).European archives of psychiatry and clinical neuroscience · 2020Article
- Morphological changes in subregions of hippocampus and amygdala in major depressive disorder patients.Brain imaging and behavior · 2020Article
- Longitudinal multi-level biomarker analysis of BDNF in major depression and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2020Article
- Reduced serum BDNF levels are associated with the increased risk for developing MDD: a case-control study with or without antidepressant therapy.BMC research notes · 2020Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a group of brain disorders with varied origins, complex genetics and obscure neurobiology. Definitions of clinical phenotypes are not rooted in their neurobiology, and animal models of behavioural despair have considerable limitations. Nevertheless, investigation of subtle alterations in gene expression, of correlations between genotype and brain activity, and of environmental variables interacting with genetic variants have advanced research into the genetics of depression. Although the postgenomic era is still in its infancy, several milestones have already been reached: variation in gene expression has been confirmed to play a predominant role in individual differences; gene-environment interactions have been established in humans and in a nonhuman primate model; gene-phenotype correlations have been substantiated by functional neuroimaging; and the notion of gene networks that control brain development is increasingly recognized. Given the etiologic and psychobiologic complexity of mood disorders, it is not surprising that the identification of specific genetic factors is extremely difficult and continues to be among the last frontiers of gene hunting.
Indexed as
Identifiers
15173894PMC400687W2171691063What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.