ArticleMolecular and cellular biochemistry2004
Various stressors rapidly activate the p38-MAPK signaling pathway in Mytilus galloprovincialis (Lam.).
Article in Molecular and cellular biochemistry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 citing papers in PubMed, 58 citations in OpenAlex.
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- Transcriptome Analysis of Marbled RockfishAnimals : an open access journal from MDPI · 2023Article
- Article
- Identification, Characterization, and Expression Analysis Reveal Diverse Regulated Roles of Three MAPK Genes inFrontiers in physiology · 2021Article
- Biomarkers of dissolved oxygen stress in oysters: a tool for restoration and management efforts.PloS one · 2014Article
- Molecular characterization and expression profile of MAP2K1ip1/MP1 gene from tiger shrimp, Penaeus monodon.Molecular biology reports · 2012Article
- MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula.Ecotoxicology (London, England) · 2011Article
- MytiBase: a knowledgebase of mussel (M. galloprovincialis) transcribed sequences.BMC genomics · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stimulation of p38-MAPK signal transduction pathway by various stressful stimuli was investigated in the marine bivalve M. galloprovincialis. Oxidative stress (5 microM H2O2) induced a biphasic pattern of p38-MAPK phosphorylation with maximal values attained at 15 min (8.1-fold) and 1 h (8.0-fold) of treatment respectively. Furthermore, 1 microM SB203580 abolished the p38-MAPK phosphorylation induced by oxidative stress. Aerial exposure also induced a biphasic pattern of p38-MAPK phosphorylation, with maximal values attained at 1 h (6.8-fold) and 8 h (4.9-fold) respectively. Re-oxygenation following a 15 min of aerial exposure resulted in the progressive dephosphorylation of the kinase. Treatment with 0.5 M sorbitol (in normal seawater) induced the rapid kinase phosphorylation (9.2-fold) and this effect was reversible. Seawater salinities varying between 100-60% had no effect, whereas a salinity of 50% induced a significant p38-MAPK phosphorylation. Furthermore, hypertonicity (120% seawater) resulted in a moderate kinase phosphorylation. All the above results demonstrate for the first time in a marine invertebrate imposed to environmental and other forms of stress as an intact, living organism, that the p38-MAPK pathway is specifically activated by various stressful stimuli which this animal can often face and sustain in vivo.
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