Trial reportEuropean journal of nuclear medicine and molecular imaging2005
Prevalence of symptomatic and silent stress-induced perfusion defects in diabetic patients with suspected coronary artery disease referred for myocardial perfusion scintigraphy.
Trial report in European journal of nuclear medicine and molecular imaging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Comparison of automated 4D-MSPECT and visual analysis for evaluating myocardial perfusion in coronary artery disease.The Kaohsiung journal of medical sciences · 2008Trial
- Using Multivariate Adaptive Regression Splines to Estimate Summed Stress Score on Myocardial Perfusion Scintigraphy in Chinese Women with Type 2 Diabetes: A Comparative Study with Multiple Linear Regression.Diagnostics (Basel, Switzerland) · 2025Article
- Comparison between multiple logistic regression and machine learning methods in prediction of abnormal thallium scans in type 2 diabetes.World journal of clinical cases · 2023Article
- Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes.Heart and vessels · 2021Article
- Significance of Microalbuminuria in Predicting Silent Myocardial Ischemia in Patients with Type 2 Diabetes Using Myocardial Perfusion ImagingMolecular imaging and radionuclide therapy · 2019Article
- Cardiovascular risk stratification in diabetic patients: is all in METS?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Article
- Inpatient management of diabetic foot disorders: a clinical guide.Diabetes care · 2013Review
- Myocardial Perfusion SPECT Utility in Predicting Cardiovascular Events Among Indonesian Diabetic Patients.The open cardiovascular medicine journal · 2013Article
- Clinical value and severity of myocardial perfusion defects in asymptomatic diabetic patients with negative or weakly positive exercise treadmill test.Asia Oceania journal of nuclear medicine & biology · 2013Article
- Prevalence and predictors of an abnormal stress myocardial perfusion study in asymptomatic patients with type 2 diabetes mellitus.European journal of nuclear medicine and molecular imaging · 2009Article
- Prevalence of myocardial ischaemia as assessed with myocardial perfusion scintigraphy in patients with diabetes mellitus type 2 and mild anginal symptoms.European journal of nuclear medicine and molecular imaging · 2006Article
- Asymptomatic patients with diabetes mellitus should be screened for coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2006Article
- Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
- Screening of asymptomatic patients with type 2 diabetes mellitus for silent coronary artery disease: combined use of stress myocardial perfusion imaging and coronary calcium scoring.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSilent myocardial ischaemia--as evaluated by stress-induced perfusion defects on myocardial perfusion scintigraphy (MPS) in patients without a history of chest pain--is frequent in diabetes and is associated with increased rates of cardiovascular events. Its prevalence has been determined in asymptomatic diabetic patients, but remains largely unknown in diabetic patients with suspected coronary artery disease (CAD) in the clinical setting. In this study we therefore sought (a) to determine the prevalence of symptomatic and silent perfusion defects in diabetic patients with suspected CAD and (b) to characterise the eventual predictors of abnormal perfusion.
methodsThe patient population comprised 133 consecutive diabetic patients with suspected CAD who had been referred for MPS. Studies were performed with exercise (41%) or pharmacological stress testing (1-day protocol, (99m)Tc-sestamibi, 201Tl or both). We used semi-quantitative analysis (20-segment polar maps) to derive the summed stress score (SSS) and the summed difference score (SDS).
resultsAbnormal MPS (SSS> or =4) was observed in 49 (37%) patients (SSS=4.9+/-8.4, SDS=2.4+/-4.7), reversible perfusion defects (SDS> or =2) in 40 (30%) patients [SSS=13.3+/-10.9; SDS=8.0+/-5.6; 20% moderate to severe (SDS>4), 7% multivessel] and fixed defects in 21 (16%) patients. Results were comparable between patients with and patients without a history of chest pain. Of 75 patients without a history of chest pain, 23 (31%, 95% CI=21-42%) presented reversible defects (SSS=13.9+/-11.3; SDS=7.4+/-1.2), indicative of silent ischaemia. Reversible defects were associated with inducible ST segment depression during MPS stress [odds ratio (OR)=3.2, p<0.01). Fixed defects were associated with erectile dysfunction in males (OR=3.7, p=0.02) and lower aspirin use (OR=0.25, p=0.02).
conclusionSilent stress-induced perfusion defects occurred in 31% of the patients, a rate similar to that in patients with a history of chest pain. MPS could identify these patients with a potentially increased risk of cardiovascular events.
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